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Surgical resection for small hepatocellular carcinoma.

Publication ,  Journal Article
Nagashima, I; Hamada, C; Naruse, K; Osada, T; Nagao, T; Kawano, N; Muto, T
Published in: Surgery
January 1996

BACKGROUND: Surgical resection for hepatocellular carcinoma (HCC) can be curative in selected patients, particularly in those with a solitary small HCC (s-sHCC; 2 cm or less in diameter). However, even these patients often have a risk of tumor recurrence or death from underlying liver dysfunction. Therefore it is important to determine which clinicopathologic features are related to the long-term prognosis after resection of s-sHCC. METHODS: Fifty patients with s-sHCC underwent partial hepatectomy at our department between 1977 and 1992. Six (12%) died of liver failure in hospital after operation. Eight clinicopathologic features were examined in the remaining 44 patients with regard to their long-term prognosis by use of univariate and multivariate analyses. RESULTS: The 1-, 3-, and 5-year survival rates were 90%, 75%, and 53%, respectively. The corresponding disease-free survival rates were 80%, 53%, and 30%, respectively. None of the following parameters was significantly related to survival rate or disease-free survival rate: presence of vascular invasion or capsular formation, the distance of free surgical margin (1 cm or more or not), serum alpha-fetoprotein level, positive hepatitis B surface antigen, and preoperative transarterial embolization. Complicated liver function was the only significant factor related to survival rate and disease-free survival rate. CONCLUSIONS: A good hepatic reserve is an important factor in treating patients with s-sHCC by surgical resection, even for a long-term prognosis. Liver transplantation should be considered for patients with severe cirrhosis and s-sHCC, even though a curative resection might be possible.

Duke Scholars

Published In

Surgery

DOI

ISSN

0039-6060

Publication Date

January 1996

Volume

119

Issue

1

Start / End Page

40 / 45

Location

United States

Related Subject Headings

  • Survival Rate
  • Surgery
  • Risk Factors
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Humans
  • Hepatectomy
  • Follow-Up Studies
 

Citation

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Nagashima, I., Hamada, C., Naruse, K., Osada, T., Nagao, T., Kawano, N., & Muto, T. (1996). Surgical resection for small hepatocellular carcinoma. Surgery, 119(1), 40–45. https://doi.org/10.1016/s0039-6060(96)80211-x
Nagashima, I., C. Hamada, K. Naruse, T. Osada, T. Nagao, N. Kawano, and T. Muto. “Surgical resection for small hepatocellular carcinoma.Surgery 119, no. 1 (January 1996): 40–45. https://doi.org/10.1016/s0039-6060(96)80211-x.
Nagashima I, Hamada C, Naruse K, Osada T, Nagao T, Kawano N, et al. Surgical resection for small hepatocellular carcinoma. Surgery. 1996 Jan;119(1):40–5.
Nagashima, I., et al. “Surgical resection for small hepatocellular carcinoma.Surgery, vol. 119, no. 1, Jan. 1996, pp. 40–45. Pubmed, doi:10.1016/s0039-6060(96)80211-x.
Nagashima I, Hamada C, Naruse K, Osada T, Nagao T, Kawano N, Muto T. Surgical resection for small hepatocellular carcinoma. Surgery. 1996 Jan;119(1):40–45.
Journal cover image

Published In

Surgery

DOI

ISSN

0039-6060

Publication Date

January 1996

Volume

119

Issue

1

Start / End Page

40 / 45

Location

United States

Related Subject Headings

  • Survival Rate
  • Surgery
  • Risk Factors
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Humans
  • Hepatectomy
  • Follow-Up Studies