Colorectal cancer metastasis determined by carbohydrate-mediated cell adhesion: role of sialyl-LeX antigens.
Human colorectal carcinomas with increased metastatic potential and with poor prognosis are characterized by the high content of sialyl-LeX carbohydrate antigens. The levels of these carbohydrate antigens apparently increase during colorectal carcinoma progression from non-metastatic to metastatic tumors. The levels of tumor-associated sialyl-LeX antigens are inversely correlated to the post surgical survival of colon carcinoma patients as revealed by retrospective studies. Cell lines selected for high levels of cell surface sialyl-LeX antigens metastasize to livers when they are injected intrasplenically into nude mice. The highly expressing cells also strongly adhere to activated endothelial cells apparently through E-selectin. We conclude that sialyl-LeX carbohydrate antigen is a unique molecular phenotype that determines colorectal cancer metastasis.
Duke Scholars
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Related Subject Headings
- Prognosis
- Oncology & Carcinogenesis
- Neoplasm Staging
- Neoplasm Metastasis
- Lewis X Antigen
- Humans
- Colorectal Neoplasms
- Cell Adhesion
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology
Citation
Published In
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Prognosis
- Oncology & Carcinogenesis
- Neoplasm Staging
- Neoplasm Metastasis
- Lewis X Antigen
- Humans
- Colorectal Neoplasms
- Cell Adhesion
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology