Colorectal cancer metastasis determined by carbohydrate-mediated cell adhesion: role of sialyl-LeX antigens.


Journal Article (Review)

Human colorectal carcinomas with increased metastatic potential and with poor prognosis are characterized by the high content of sialyl-LeX carbohydrate antigens. The levels of these carbohydrate antigens apparently increase during colorectal carcinoma progression from non-metastatic to metastatic tumors. The levels of tumor-associated sialyl-LeX antigens are inversely correlated to the post surgical survival of colon carcinoma patients as revealed by retrospective studies. Cell lines selected for high levels of cell surface sialyl-LeX antigens metastasize to livers when they are injected intrasplenically into nude mice. The highly expressing cells also strongly adhere to activated endothelial cells apparently through E-selectin. We conclude that sialyl-LeX carbohydrate antigen is a unique molecular phenotype that determines colorectal cancer metastasis.

Full Text

Duke Authors

Cited Authors

  • Irimura, T; Nakamori, S; Matsushita, Y; Taniuchi, Y; Todoroki, N; Tsuji, T; Izumi, Y; Kawamura, Y; Hoff, SD; Cleary, KR

Published Date

  • October 1993

Published In

Volume / Issue

  • 4 / 5

Start / End Page

  • 319 - 324

PubMed ID

  • 7903054

Pubmed Central ID

  • 7903054

International Standard Serial Number (ISSN)

  • 1044-579X


  • eng

Conference Location

  • England