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Metastatic potential of colon carcinoma. Expression of ABO/Lewis-related antigens.

Publication ,  Journal Article
Hoff, SD; Irimura, T; Matsushita, Y; Ota, DM; Cleary, KR; Hakomori, S
Published in: Arch Surg
February 1990

Four monoclonal antibodies specific to various Lewisx-related antigens were tested for binding to monolayers and detergent extracts of the human colon carcinoma cell line HT-29 P and its metastatic variant HT-29 LMM. Only monoclonal antibody FH6 (antisialyl-dimeric Lex) bound more to the metastatic variant compared with HT-29 P. Detergent extracts of human tissues were then assayed for their FH6-binding activity. Normal colonic mucosa displayed less FH6 binding than either Dukes stage B or D primary colon carcinomas. Liver metastases from colorectal carcinoma demonstrated greater binding than stage B and stage D primary tumors, and more than normal liver. Expression of sialyl-dimeric Lex increases as the metastatic potential of colorectal carcinomas increases, and is related to the progression of colorectal cancer.

Duke Scholars

Published In

Arch Surg

DOI

ISSN

0004-0010

Publication Date

February 1990

Volume

125

Issue

2

Start / End Page

206 / 209

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Surgery
  • Liver Neoplasms
  • Liver
  • Lewis Blood Group Antigens
  • Isoantigens
  • Intestinal Mucosa
  • Humans
  • Colonic Neoplasms
  • Colon
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hoff, S. D., Irimura, T., Matsushita, Y., Ota, D. M., Cleary, K. R., & Hakomori, S. (1990). Metastatic potential of colon carcinoma. Expression of ABO/Lewis-related antigens. Arch Surg, 125(2), 206–209. https://doi.org/10.1001/archsurg.1990.01410140084013
Hoff, S. D., T. Irimura, Y. Matsushita, D. M. Ota, K. R. Cleary, and S. Hakomori. “Metastatic potential of colon carcinoma. Expression of ABO/Lewis-related antigens.Arch Surg 125, no. 2 (February 1990): 206–9. https://doi.org/10.1001/archsurg.1990.01410140084013.
Hoff SD, Irimura T, Matsushita Y, Ota DM, Cleary KR, Hakomori S. Metastatic potential of colon carcinoma. Expression of ABO/Lewis-related antigens. Arch Surg. 1990 Feb;125(2):206–9.
Hoff, S. D., et al. “Metastatic potential of colon carcinoma. Expression of ABO/Lewis-related antigens.Arch Surg, vol. 125, no. 2, Feb. 1990, pp. 206–09. Pubmed, doi:10.1001/archsurg.1990.01410140084013.
Hoff SD, Irimura T, Matsushita Y, Ota DM, Cleary KR, Hakomori S. Metastatic potential of colon carcinoma. Expression of ABO/Lewis-related antigens. Arch Surg. 1990 Feb;125(2):206–209.

Published In

Arch Surg

DOI

ISSN

0004-0010

Publication Date

February 1990

Volume

125

Issue

2

Start / End Page

206 / 209

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Surgery
  • Liver Neoplasms
  • Liver
  • Lewis Blood Group Antigens
  • Isoantigens
  • Intestinal Mucosa
  • Humans
  • Colonic Neoplasms
  • Colon