Evaluation of continuous-infusion alpha-difluoromethylornithine therapy for colorectal carcinoma.
Journal Article (Journal Article)
A total of 32 evaluable patients with measurable advanced colorectal carcinoma were treated with continuous-infusion alpha-difluoromethylornithine (DFMO) at a median daily dose of 8 g/m2 (range, 6-14 g/m2). DFMO was infused over 24 h daily for 28 days, followed by a rest period of 7 days. Of the 32 patients, 14 had received no prior chemotherapy. A total of 65 courses was given, with the median being 2 (range, 1-9 courses). None of the patients achieved a partial or complete response; however, 3 patients achieved a minor response and 14 had stable disease. The frequent toxic effects of DFMO included thrombocytopenia (which was dose-limiting), malaise, nausea, vomiting, reversible hearing loss, and diarrhea. Our data suggest that continuous-infusion DFMO therapy is feasible and results in only mild gastrointestinal toxicity. Although DFMO proved to be ineffective as a single agent in this trial, it could probably best be used in combination with cytotoxic agents known to enhance its antitumor activity in a preclinical setting.
Full Text
Duke Authors
Cited Authors
- Ajani, JA; Ota, DM; Grossie, VB; Abbruzzese, JL; Faintuch, JS; Patt, YZ; Jackson, DE; Levin, B; Nishioka, K
Published Date
- 1990
Published In
Volume / Issue
- 26 / 3
Start / End Page
- 223 - 226
PubMed ID
- 2113439
International Standard Serial Number (ISSN)
- 0344-5704
Digital Object Identifier (DOI)
- 10.1007/BF02897204
Language
- eng
Conference Location
- Germany