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Acoustic radiation force impulse imaging of vulnerable plaques: a finite element method parametric analysis.

Publication ,  Journal Article
Doherty, JR; Dumont, DM; Trahey, GE; Palmeri, ML
Published in: Journal of biomechanics
January 2013

Plaque rupture is the most common cause of complications such as stroke and coronary heart failure. Recent histopathological evidence suggests that several plaque features, including a large lipid core and a thin fibrous cap, are associated with plaques most at risk for rupture. Acoustic Radiation Force Impulse (ARFI) imaging, a recently developed ultrasound-based elasticity imaging technique, shows promise for imaging these features noninvasively. Clinically, this could be used to distinguish vulnerable plaques, for which surgical intervention may be required, from those less prone to rupture. In this study, a parametric analysis using Finite Element Method (FEM) models was performed to simulate ARFI imaging of five different carotid artery plaques across a wide range of material properties. It was demonstrated that ARFI imaging could resolve the softer lipid pool from the surrounding, stiffer media and fibrous cap and was most dependent upon the stiffness of the lipid pool component. Stress concentrations due to an ARFI excitation were located in the media and fibrous cap components. In all cases, the maximum Von Mises stress was<1.2 kPa. In comparing these results with others investigating plaque rupture, it is concluded that while the mechanisms may be different, the Von Mises stresses imposed by ARFI imaging are orders of magnitude lower than the stresses associated with blood pressure.

Duke Scholars

Published In

Journal of biomechanics

DOI

EISSN

1873-2380

ISSN

0021-9290

Publication Date

January 2013

Volume

46

Issue

1

Start / End Page

83 / 90

Related Subject Headings

  • Plaque, Atherosclerotic
  • Humans
  • Finite Element Analysis
  • Elasticity Imaging Techniques
  • Elastic Modulus
  • Computer Simulation
  • Carotid Artery Diseases
  • Biomedical Engineering
  • 4207 Sports science and exercise
  • 4003 Biomedical engineering
 

Citation

APA
Chicago
ICMJE
MLA
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Doherty, J. R., Dumont, D. M., Trahey, G. E., & Palmeri, M. L. (2013). Acoustic radiation force impulse imaging of vulnerable plaques: a finite element method parametric analysis. Journal of Biomechanics, 46(1), 83–90. https://doi.org/10.1016/j.jbiomech.2012.10.006
Doherty, Joshua R., Douglas M. Dumont, Gregg E. Trahey, and Mark L. Palmeri. “Acoustic radiation force impulse imaging of vulnerable plaques: a finite element method parametric analysis.Journal of Biomechanics 46, no. 1 (January 2013): 83–90. https://doi.org/10.1016/j.jbiomech.2012.10.006.
Doherty JR, Dumont DM, Trahey GE, Palmeri ML. Acoustic radiation force impulse imaging of vulnerable plaques: a finite element method parametric analysis. Journal of biomechanics. 2013 Jan;46(1):83–90.
Doherty, Joshua R., et al. “Acoustic radiation force impulse imaging of vulnerable plaques: a finite element method parametric analysis.Journal of Biomechanics, vol. 46, no. 1, Jan. 2013, pp. 83–90. Epmc, doi:10.1016/j.jbiomech.2012.10.006.
Doherty JR, Dumont DM, Trahey GE, Palmeri ML. Acoustic radiation force impulse imaging of vulnerable plaques: a finite element method parametric analysis. Journal of biomechanics. 2013 Jan;46(1):83–90.
Journal cover image

Published In

Journal of biomechanics

DOI

EISSN

1873-2380

ISSN

0021-9290

Publication Date

January 2013

Volume

46

Issue

1

Start / End Page

83 / 90

Related Subject Headings

  • Plaque, Atherosclerotic
  • Humans
  • Finite Element Analysis
  • Elasticity Imaging Techniques
  • Elastic Modulus
  • Computer Simulation
  • Carotid Artery Diseases
  • Biomedical Engineering
  • 4207 Sports science and exercise
  • 4003 Biomedical engineering