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Peptide YY: a gut hormone associated with anorexia during infectious diarrhea in children.

Publication ,  Journal Article
Beck, AL; Cabrera, L; Pan, WKY; Cama, V; Friedland, JS; Ghatei, MA; Bloom, SR; Lewis, J; Gilman, RH
Published in: The Journal of pediatrics
November 2008

To evaluate the effects of diarrhea on appetite among Peruvian children age 12 to 71 months and to assess whether elevated plasma levels of peptide YY, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1beta contribute to anorexia in this population.A total of 46 Peruvian children with diarrhea and 46 healthy controls underwent an observed feeding trial that was repeated when cases were healthy. Blood samples were obtained from 30 cases and 30 controls at the first trial and from 30 cases at the second trial and assayed for peptide YY, TNF-alpha, and IL-1beta.In the cases, mean consumption was less when sick than when healthy. The mean plasma level of peptide YY was higher for cases than controls and higher for cases when sick than when healthy. TNF-alpha levels were higher in cases than controls at visit 1 and also higher in cases when sick than when healthy. There were no differences in IL-1beta levels between cases and controls or between cases when sick and healthy. Peptide YY levels in children with diarrhea correlated with the likelihood of them eating less when sick than when healthy.Elevated serum peptide YY may be a mechanism for anorexia in children with diarrhea.

Duke Scholars

Published In

The Journal of pediatrics

DOI

EISSN

1097-6833

ISSN

0022-3476

Publication Date

November 2008

Volume

153

Issue

5

Start / End Page

677 / 682

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Treatment Outcome
  • Peptide YY
  • Pediatrics
  • Male
  • Intestinal Mucosa
  • Interleukin-1beta
  • Infant
  • Humans
  • Gastrointestinal Hormones
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Beck, A. L., Cabrera, L., Pan, W. K. Y., Cama, V., Friedland, J. S., Ghatei, M. A., … Gilman, R. H. (2008). Peptide YY: a gut hormone associated with anorexia during infectious diarrhea in children. The Journal of Pediatrics, 153(5), 677–682. https://doi.org/10.1016/j.jpeds.2008.04.065
Beck, Amy L., Lilia Cabrera, William K. Y. Pan, Vitaliano Cama, Jon S. Friedland, Mohammad A. Ghatei, Stephen R. Bloom, Judy Lewis, and Robert H. Gilman. “Peptide YY: a gut hormone associated with anorexia during infectious diarrhea in children.The Journal of Pediatrics 153, no. 5 (November 2008): 677–82. https://doi.org/10.1016/j.jpeds.2008.04.065.
Beck AL, Cabrera L, Pan WKY, Cama V, Friedland JS, Ghatei MA, et al. Peptide YY: a gut hormone associated with anorexia during infectious diarrhea in children. The Journal of pediatrics. 2008 Nov;153(5):677–82.
Beck, Amy L., et al. “Peptide YY: a gut hormone associated with anorexia during infectious diarrhea in children.The Journal of Pediatrics, vol. 153, no. 5, Nov. 2008, pp. 677–82. Epmc, doi:10.1016/j.jpeds.2008.04.065.
Beck AL, Cabrera L, Pan WKY, Cama V, Friedland JS, Ghatei MA, Bloom SR, Lewis J, Gilman RH. Peptide YY: a gut hormone associated with anorexia during infectious diarrhea in children. The Journal of pediatrics. 2008 Nov;153(5):677–682.
Journal cover image

Published In

The Journal of pediatrics

DOI

EISSN

1097-6833

ISSN

0022-3476

Publication Date

November 2008

Volume

153

Issue

5

Start / End Page

677 / 682

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Treatment Outcome
  • Peptide YY
  • Pediatrics
  • Male
  • Intestinal Mucosa
  • Interleukin-1beta
  • Infant
  • Humans
  • Gastrointestinal Hormones