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Diagnosis of cystic echinococcosis, central Peruvian Highlands.

Publication ,  Journal Article
Gavidia, CM; Gonzalez, AE; Zhang, W; McManus, DP; Lopera, L; Ninaquispe, B; Garcia, HH; Rodríguez, S; Verastegui, M; Calderon, C; Pan, WKY; Gilman, RH
Published in: Emerging infectious diseases
February 2008

We evaluated prevalence of cystic echinococcosis (CE) in a central Peruvian Highland district by using 4 diagnostic methods: ultrasonography for 949 persons, radiography for 829, and 2 serologic tests for 929 (2 immunoblot formats using bovine hydatid cyst fluid [IBCF] and recombinant EpC1 glutathione S-transferase [rEpC1-GST] antigens). For the IBCF and rEpC1-GST testing, prevalence of liver and pulmonary CE was 4.7% and 1.1% and seropositivity was 8.9% and 19.7%, respectively. Frequency of seropositive results for IBCF and rEpC1-GST testing was 35.7% and 16.7% (all hepatic cysts), 47.1% and 29.4% (hepatic calcifications excluded), and 22.2% and 33.3% (lung cysts), respectively. Weak immune response against lung cysts, calcified cysts, small cysts, and cysts in sites other than lung and liver might explain the poor performance of the serodiagnostic tests. We confirm that CE is highly endemic to Peru and emphasize the limited performance of available serologic assays in the field.

Duke Scholars

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Published In

Emerging infectious diseases

DOI

EISSN

1080-6059

ISSN

1080-6040

Publication Date

February 2008

Volume

14

Issue

2

Start / End Page

260 / 266

Related Subject Headings

  • Ultrasonography
  • Rural Population
  • Radiography
  • Prevalence
  • Peru
  • Microbiology
  • Male
  • Lung
  • Liver
  • Immunoblotting
 

Citation

APA
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Gavidia, C. M., Gonzalez, A. E., Zhang, W., McManus, D. P., Lopera, L., Ninaquispe, B., … Gilman, R. H. (2008). Diagnosis of cystic echinococcosis, central Peruvian Highlands. Emerging Infectious Diseases, 14(2), 260–266. https://doi.org/10.3201/eid1402.061101
Gavidia, Cesar M., Armando E. Gonzalez, Wenbao Zhang, Donald P. McManus, Luis Lopera, Berenice Ninaquispe, Hector H. Garcia, et al. “Diagnosis of cystic echinococcosis, central Peruvian Highlands.Emerging Infectious Diseases 14, no. 2 (February 2008): 260–66. https://doi.org/10.3201/eid1402.061101.
Gavidia CM, Gonzalez AE, Zhang W, McManus DP, Lopera L, Ninaquispe B, et al. Diagnosis of cystic echinococcosis, central Peruvian Highlands. Emerging infectious diseases. 2008 Feb;14(2):260–6.
Gavidia, Cesar M., et al. “Diagnosis of cystic echinococcosis, central Peruvian Highlands.Emerging Infectious Diseases, vol. 14, no. 2, Feb. 2008, pp. 260–66. Epmc, doi:10.3201/eid1402.061101.
Gavidia CM, Gonzalez AE, Zhang W, McManus DP, Lopera L, Ninaquispe B, Garcia HH, Rodríguez S, Verastegui M, Calderon C, Pan WKY, Gilman RH. Diagnosis of cystic echinococcosis, central Peruvian Highlands. Emerging infectious diseases. 2008 Feb;14(2):260–266.

Published In

Emerging infectious diseases

DOI

EISSN

1080-6059

ISSN

1080-6040

Publication Date

February 2008

Volume

14

Issue

2

Start / End Page

260 / 266

Related Subject Headings

  • Ultrasonography
  • Rural Population
  • Radiography
  • Prevalence
  • Peru
  • Microbiology
  • Male
  • Lung
  • Liver
  • Immunoblotting