Persistent pain associated with long-term intrathecal morphine administration.
Publication
, Journal Article
Parris, WC; Janicki, PK; Johnson, B; Livengood, J; Mathews, L
Published in: South Med J
April 1996
A 32-year-old man with chronic intractable right lower extremity pain unresponsive to multiple neurosurgical and pharmacologic treatments, including intrathecal morphine administration, was successfully treated with sciatic nerve block, discontinuance of opioid therapy, and psychologic interventions. Plasma and urine ratios of morphine metabolites morphine-3-glucuronide and morphine-6-glucuronide were analyzed at the beginning of our interventions, and the results indicated that morphine-3-glucuronide levels were significantly higher than morphine-6-glucuronide levels. The possible association between the observed morphine metabolite ratio and the intractable pain in patients resistant to opioids may have potential clinical implications.
Duke Scholars
Published In
South Med J
DOI
ISSN
0038-4348
Publication Date
April 1996
Volume
89
Issue
4
Start / End Page
417 / 419
Location
United States
Related Subject Headings
- Treatment Failure
- Pain, Intractable
- Nerve Block
- Morphine Derivatives
- Morphine
- Male
- Injections, Spinal
- Humans
- General & Internal Medicine
- Drug Resistance
Citation
APA
Chicago
ICMJE
MLA
NLM
Parris, W. C., Janicki, P. K., Johnson, B., Livengood, J., & Mathews, L. (1996). Persistent pain associated with long-term intrathecal morphine administration. South Med J, 89(4), 417–419. https://doi.org/10.1097/00007611-199604000-00014
Parris, W. C., P. K. Janicki, B. Johnson, J. Livengood, and L. Mathews. “Persistent pain associated with long-term intrathecal morphine administration.” South Med J 89, no. 4 (April 1996): 417–19. https://doi.org/10.1097/00007611-199604000-00014.
Parris WC, Janicki PK, Johnson B, Livengood J, Mathews L. Persistent pain associated with long-term intrathecal morphine administration. South Med J. 1996 Apr;89(4):417–9.
Parris, W. C., et al. “Persistent pain associated with long-term intrathecal morphine administration.” South Med J, vol. 89, no. 4, Apr. 1996, pp. 417–19. Pubmed, doi:10.1097/00007611-199604000-00014.
Parris WC, Janicki PK, Johnson B, Livengood J, Mathews L. Persistent pain associated with long-term intrathecal morphine administration. South Med J. 1996 Apr;89(4):417–419.
Published In
South Med J
DOI
ISSN
0038-4348
Publication Date
April 1996
Volume
89
Issue
4
Start / End Page
417 / 419
Location
United States
Related Subject Headings
- Treatment Failure
- Pain, Intractable
- Nerve Block
- Morphine Derivatives
- Morphine
- Male
- Injections, Spinal
- Humans
- General & Internal Medicine
- Drug Resistance