Immunoreactive substance P is decreased in saliva of patients with chronic back pain syndromes.


Journal Article

Substance P, a neuropeptide associated with pain perception, is widely distributed in the central nervous system and is decreased in the cerebrospinal fluid of chronic pain patients as compared with that of healthy human volunteers. In this study, we have demonstrated the presence of immunoreactive substance P in saliva and further, that both saliva and plasma levels of immunoreactive substance P are lower in patients with chronic low back pain than in healthy human volunteers. To our knowledge, this is the first time that substance P has been identified in human saliva. These findings, together with the noninvasive nature of saliva collection, suggest that substance P in saliva may be useful as an alternative neurochemical correlate of chronic low back pain when collection of cerebrospinal fluid and plasma samples for substance P analysis is unacceptable or inappropriate.

Full Text

Duke Authors

Cited Authors

  • Parris, WC; Kambam, JR; Naukam, RJ; Rama Sastry, BV

Published Date

  • January 1990

Published In

Volume / Issue

  • 70 / 1

Start / End Page

  • 63 - 67

PubMed ID

  • 1688690

Pubmed Central ID

  • 1688690

International Standard Serial Number (ISSN)

  • 0003-2999

Digital Object Identifier (DOI)

  • 10.1213/00000539-199001000-00010


  • eng

Conference Location

  • United States