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Immunoreactive substance P is decreased in saliva of patients with chronic back pain syndromes.

Publication ,  Journal Article
Parris, WC; Kambam, JR; Naukam, RJ; Rama Sastry, BV
Published in: Anesth Analg
January 1990

Substance P, a neuropeptide associated with pain perception, is widely distributed in the central nervous system and is decreased in the cerebrospinal fluid of chronic pain patients as compared with that of healthy human volunteers. In this study, we have demonstrated the presence of immunoreactive substance P in saliva and further, that both saliva and plasma levels of immunoreactive substance P are lower in patients with chronic low back pain than in healthy human volunteers. To our knowledge, this is the first time that substance P has been identified in human saliva. These findings, together with the noninvasive nature of saliva collection, suggest that substance P in saliva may be useful as an alternative neurochemical correlate of chronic low back pain when collection of cerebrospinal fluid and plasma samples for substance P analysis is unacceptable or inappropriate.

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Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

January 1990

Volume

70

Issue

1

Start / End Page

63 / 67

Location

United States

Related Subject Headings

  • Substance P
  • Saliva
  • Middle Aged
  • Male
  • Humans
  • Female
  • Back Pain
  • Anesthesiology
  • 3202 Clinical sciences
  • 1109 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
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Parris, W. C., Kambam, J. R., Naukam, R. J., & Rama Sastry, B. V. (1990). Immunoreactive substance P is decreased in saliva of patients with chronic back pain syndromes. Anesth Analg, 70(1), 63–67. https://doi.org/10.1213/00000539-199001000-00010
Parris, W. C., J. R. Kambam, R. J. Naukam, and B. V. Rama Sastry. “Immunoreactive substance P is decreased in saliva of patients with chronic back pain syndromes.Anesth Analg 70, no. 1 (January 1990): 63–67. https://doi.org/10.1213/00000539-199001000-00010.
Parris WC, Kambam JR, Naukam RJ, Rama Sastry BV. Immunoreactive substance P is decreased in saliva of patients with chronic back pain syndromes. Anesth Analg. 1990 Jan;70(1):63–7.
Parris, W. C., et al. “Immunoreactive substance P is decreased in saliva of patients with chronic back pain syndromes.Anesth Analg, vol. 70, no. 1, Jan. 1990, pp. 63–67. Pubmed, doi:10.1213/00000539-199001000-00010.
Parris WC, Kambam JR, Naukam RJ, Rama Sastry BV. Immunoreactive substance P is decreased in saliva of patients with chronic back pain syndromes. Anesth Analg. 1990 Jan;70(1):63–67.

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

January 1990

Volume

70

Issue

1

Start / End Page

63 / 67

Location

United States

Related Subject Headings

  • Substance P
  • Saliva
  • Middle Aged
  • Male
  • Humans
  • Female
  • Back Pain
  • Anesthesiology
  • 3202 Clinical sciences
  • 1109 Neurosciences