In vitro effects of fluoride and bromide on pseudocholinesterase and acetylcholinesterase activities.


Journal Article

The in vitro effects of two metabolites of inhalational anaesthetics, fluoride and bromide, on pseudocholinesterase (PCHE) and acetylcholinesterase (ACHE) activities in the blood samples of seven healthy patients were studied. The PCHE and ACHE activities were determined by kinetic spectrophotometric methods. Fluoride at the levels achieved with clinical concentrations of enflurane and sevoflurane (25-75 microM.L-1) inhibited PCHE activity by 28-65 per cent (P less than 0.01) and ACHE activity by less than five per cent (P greater than 0.05). Bromide at the levels achieved with clinical concentrations of inhalational anaesthetics had no significant effect on either PCHE or ACHE activity. We recommend caution when succinylcholine and/or ester type local anaesthetics are used in the immediate postoperative period following enflurane or sevoflurane anaesthesia. We also recommend that blood drawing for PCHE activity be delayed at least until 24 hr following enflurane or sevoflurane anaesthesia.

Full Text

Duke Authors

Cited Authors

  • Kambam, JR; Parris, WC; Naukam, RJ; Franks, JJ; Sastry, BV

Published Date

  • November 1990

Published In

Volume / Issue

  • 37 / 8

Start / End Page

  • 916 - 919

PubMed ID

  • 2253299

Pubmed Central ID

  • 2253299

International Standard Serial Number (ISSN)

  • 0832-610X

Digital Object Identifier (DOI)

  • 10.1007/BF03006636


  • eng

Conference Location

  • United States