Pseudocholinesterase activity in human cerebrospinal fluid.

Published

Journal Article

Pseudocholinesterase (PCHE) activity and dibucaine numbers (DN) in the cerebrospinal fluid (CSF) and plasma of 10 ASA physical status 1 and 2 patients were measured using a kinetic method. CSF had a mean PCHE activity of 0.018 +/- 0.013 unit/ml with a DN of 59 +/- 4. Whereas, PCHE activity and DN in the plasma were 0.960 +/- 0.12 units/ml and 84 +/- 3, respectively. We also measured PCHE activity and DN in the CSF and plasma of 4 patients in whom there was a recent history of intraventricular bleeding. These patients had a CSF PCHE activity of 0.340 +/- 0.07 units/ml (DN = 78 +/- 3) and a plasma PCHE activity of 0.950 +/- 0.10 units/ml (DN = 82 +/- 2). Our data show that there is a low activity of PCHE in CSF, 1/20-1/100th that of plasma. Our data also show that PCHE activity increased to 1/4 to 1/2 that of plasma in CSF of patients with bleeding into CSF.

Full Text

Duke Authors

Cited Authors

  • Kambam, JR; Horton, B; Parris, WC; Hyman, SA; Berman, ML; Sastry, BV

Published Date

  • April 1989

Published In

Volume / Issue

  • 68 / 4

Start / End Page

  • 486 - 488

PubMed ID

  • 2929981

Pubmed Central ID

  • 2929981

International Standard Serial Number (ISSN)

  • 0003-2999

Language

  • eng

Conference Location

  • United States