The inhibitory effect of metoclopramide on plasma cholinesterase activity.
Journal Article (Journal Article)
The in vitro effect of metoclopramide on plasma cholinesterase (PCHE) activity was studied to investigate a mechanism for metoclopramide-induced prolongation of succinylcholine action. The mean PCHE of the control samples was 0.86 +/- 0.02 unit.ml-1. PCHE activity in the presence of metoclopramide, at concentrations of 0.05, 0.10, 0.50, 1.0, 2.5 and 5.0 micrograms.ml-1, was reduced to 0.78 +/- 0.02, 0.69 +/- 0.04, 0.50 +/- 0.03, 0.39 +/- 0.02, 0.24 +/- 0.01 and 0.15 +/- 0.01 unit.ml-1, respectively. Our data demonstrated that PCHE activity was significantly depressed by metoclopramide at all concentrations studied (p less than 0.001). Our data also show that the concentration of metoclopramide required to inhibit 50 per cent of PCHE activity (I50) was 0.8 micrograms.ml-1 (2.4 x 10(-6) M). We recommend caution when succinylcholine and or ester type local anaesthetics are administered to patients who are also receiving metoclopramide, especially in high doses.
Full Text
Duke Authors
Cited Authors
- Kambam, JR; Parris, WC; Franks, JJ; Sastry, BV; Naukam, R; Smith, BE
Published Date
- September 1988
Published In
Volume / Issue
- 35 / 5
Start / End Page
- 476 - 478
PubMed ID
- 3273154
International Standard Serial Number (ISSN)
- 0832-610X
Digital Object Identifier (DOI)
- 10.1007/BF03026894
Language
- eng
Conference Location
- United States