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Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass.

Publication ,  Journal Article
Yang, W; Ma, Q; Mackensen, GB; Paschen, W
Published in: J Cereb Blood Flow Metab
May 2009

Various cardiovascular operations are performed during conditions of deep hypothermic circulatory arrest. Here we investigated the effects of deep hypothermia on the small ubiquitin-like modifier (SUMO) conjugation pathway using a clinically relevant animal model of deep hypothermic cardiopulmonary bypass (DHCPB). Deep hypothermic cardiopulmonary bypass induced a marked activation of the SUMO conjugation pathway and triggered a nuclear translocation of SUMO2/3-conjugated proteins. Furthermore, DHCBP significantly modified gene expression. Activation of the SUMO conjugation pathway is believed to protect neurons from damage caused by low blood flow. This pathway may, therefore, play a key role in defining the outcome of cells exposed to DHCPB.

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Published In

J Cereb Blood Flow Metab

DOI

EISSN

1559-7016

Publication Date

May 2009

Volume

29

Issue

5

Start / End Page

886 / 890

Location

United States

Related Subject Headings

  • Small Ubiquitin-Related Modifier Proteins
  • Rats, Sprague-Dawley
  • Rats
  • Protein Transport
  • Neurology & Neurosurgery
  • Microscopy, Confocal
  • Male
  • Gene Expression
  • Cytoplasm
  • Circulatory Arrest, Deep Hypothermia Induced
 

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Yang, W., Ma, Q., Mackensen, G. B., & Paschen, W. (2009). Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass. J Cereb Blood Flow Metab, 29(5), 886–890. https://doi.org/10.1038/jcbfm.2009.16
Yang, Wei, Qing Ma, G Burkhard Mackensen, and Wulf Paschen. “Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass.J Cereb Blood Flow Metab 29, no. 5 (May 2009): 886–90. https://doi.org/10.1038/jcbfm.2009.16.
Yang, Wei, et al. “Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass.J Cereb Blood Flow Metab, vol. 29, no. 5, May 2009, pp. 886–90. Pubmed, doi:10.1038/jcbfm.2009.16.
Journal cover image

Published In

J Cereb Blood Flow Metab

DOI

EISSN

1559-7016

Publication Date

May 2009

Volume

29

Issue

5

Start / End Page

886 / 890

Location

United States

Related Subject Headings

  • Small Ubiquitin-Related Modifier Proteins
  • Rats, Sprague-Dawley
  • Rats
  • Protein Transport
  • Neurology & Neurosurgery
  • Microscopy, Confocal
  • Male
  • Gene Expression
  • Cytoplasm
  • Circulatory Arrest, Deep Hypothermia Induced