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Β-arrestin: a signaling molecule and potential therapeutic target for heart failure.

Publication ,  Journal Article
Noor, N; Patel, CB; Rockman, HA
Published in: J Mol Cell Cardiol
October 2011

Currently, some of the most effective treatments for heart failure target GPCRs such as the beta-adrenergic receptors (β1AR and β2AR) and angiotensin II type IA receptors (AT1aR). Ligands for these receptors not only function by blocking the deleterious G-protein mediated pathway leading to heart failure, but also signal via G-protein independent pathways that involve receptor phosphorylation by G-protein receptor kinases (GRKs) leading to recruitment of the multifunctional protein, β-arrestin. Originally thought to play a role in GPCR desensitization and internalization, β-arrestin has recently been shown to mediate signaling independent of classical second messengers in a way that is often protective to the heart. The multi-functionality of β-arrestin makes it an intriguing molecule in the development of the next generation of drugs for cardiac diseases with the potential to simultaneously inhibit deleterious G-protein dependent pathways while activating beneficial β-arrestin mediated signaling. In this review, we explore various facets of β-arrestin signaling and offer a perspective on its potential role as a key signaling molecule in the treatment of heart failure. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure."

Duke Scholars

Published In

J Mol Cell Cardiol

DOI

EISSN

1095-8584

Publication Date

October 2011

Volume

51

Issue

4

Start / End Page

534 / 541

Location

England

Related Subject Headings

  • beta-Arrestins
  • Signal Transduction
  • Receptors, G-Protein-Coupled
  • Receptors, Angiotensin
  • Receptors, Adrenergic, beta-1
  • Proteolysis
  • Protein Transport
  • Protein Conformation
  • Myocardium
  • Molecular Targeted Therapy
 

Citation

APA
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ICMJE
MLA
NLM
Noor, N., Patel, C. B., & Rockman, H. A. (2011). Β-arrestin: a signaling molecule and potential therapeutic target for heart failure. J Mol Cell Cardiol, 51(4), 534–541. https://doi.org/10.1016/j.yjmcc.2010.11.005
Noor, Nabila, Chetan B. Patel, and Howard A. Rockman. “Β-arrestin: a signaling molecule and potential therapeutic target for heart failure.J Mol Cell Cardiol 51, no. 4 (October 2011): 534–41. https://doi.org/10.1016/j.yjmcc.2010.11.005.
Noor N, Patel CB, Rockman HA. Β-arrestin: a signaling molecule and potential therapeutic target for heart failure. J Mol Cell Cardiol. 2011 Oct;51(4):534–41.
Noor, Nabila, et al. “Β-arrestin: a signaling molecule and potential therapeutic target for heart failure.J Mol Cell Cardiol, vol. 51, no. 4, Oct. 2011, pp. 534–41. Pubmed, doi:10.1016/j.yjmcc.2010.11.005.
Noor N, Patel CB, Rockman HA. Β-arrestin: a signaling molecule and potential therapeutic target for heart failure. J Mol Cell Cardiol. 2011 Oct;51(4):534–541.
Journal cover image

Published In

J Mol Cell Cardiol

DOI

EISSN

1095-8584

Publication Date

October 2011

Volume

51

Issue

4

Start / End Page

534 / 541

Location

England

Related Subject Headings

  • beta-Arrestins
  • Signal Transduction
  • Receptors, G-Protein-Coupled
  • Receptors, Angiotensin
  • Receptors, Adrenergic, beta-1
  • Proteolysis
  • Protein Transport
  • Protein Conformation
  • Myocardium
  • Molecular Targeted Therapy