FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.

Journal Article (Journal Article)

AIM: To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus (HCV) cohort. METHODS: Patients with chronic HCV were randomized to receive interferon-based therapy for 24 (genotypes 2/3) or 48 (genotype 1) wk. FibroSURE™ (FS) was assessed at baseline and at week-12 post-treatment follow-up. Baseline biopsy for METAVIR was assessed by a single pathologist. FibroScan(®) transient elastography (TE) was performed during treatment in a patient subset. RESULTS: Two thousand and sixty patients (n = 253 in Asia) were classified as METAVIR F0-1 (n = 1682) or F2-4 (n = 378). For F2-4, FS (n = 2055) had sensitivity and specificity of 0.87 and 0.61, respectively, with area under the receiver-operating curve of 0.82; corresponding values for TE (n = 214) and combined FS/TE (n = 209) were 0.77, 0.88 and 0.88, and 0.93, 0.68 and 0.88. Overall FS/TE agreement for F2-4 was 71% (κ = 0.41) and higher in Asians vs non-Asians (κ = 0.86 vs 0.35; P < 0.001). Combined FS/TE had 97% accuracy in Asians (n = 33). Baseline FS (0.38 vs 0.51, P < 0.001) and TE (8.0 kPa vs 11.9 kPa, P = 0.006) scores were lower in patients with sustained virological response than in nonresponders, and were maintained through follow-up. CONCLUSION: FS and TE may reliably differentiate mild from moderate-advanced disease, with a potential for high diagnostic accuracy in Asians with chronic HCV.

Full Text

Duke Authors

Cited Authors

  • Patel, K; Friedrich-Rust, M; Lurie, Y; Grigorescu, M; Stanciu, C; Lee, C-M; Schiff, ER; Häussinger, D; Manns, MP; Gerken, G; Colle, I; Torbenson, M; Pulkstenis, E; Subramanian, GM; McHutchison, JG; Zeuzem, S

Published Date

  • November 7, 2011

Published In

Volume / Issue

  • 17 / 41

Start / End Page

  • 4581 - 4589

PubMed ID

  • 22147963

Pubmed Central ID

  • PMC3225094

Electronic International Standard Serial Number (EISSN)

  • 2219-2840

Digital Object Identifier (DOI)

  • 10.3748/wjg.v17.i41.4581


  • eng

Conference Location

  • United States