Biomarkers of liver fibrosis: what lies beneath the receiver operating characteristic curve?
Publication
, Journal Article
Guha, IN; Myers, RP; Patel, K; Talwalkar, JA
Published in: Hepatology
October 2011
Noninvasive biomarkers of liver fibrosis represent an intense area of research with the goals of improving patient care, disease stratification, and aiding the development of future antifibrotic therapies. Despite the rapid progress in recent years, there remain questions about how diagnostic studies are designed, statistical methods to account for spectrum bias, clinically relevant thresholds of fibrosis that should be delineated, how diagnostics can be improved, and strengthening the reference test to judge emerging biomarkers. This review discusses the current methods to address these issues and where further progress is needed.
Duke Scholars
Published In
Hepatology
DOI
EISSN
1527-3350
Publication Date
October 2011
Volume
54
Issue
4
Start / End Page
1454 / 1462
Location
United States
Related Subject Headings
- United Kingdom
- Severity of Illness Index
- ROC Curve
- Predictive Value of Tests
- Male
- Liver Cirrhosis
- Humans
- Gastroenterology & Hepatology
- Female
- Biomarkers
Citation
APA
Chicago
ICMJE
MLA
NLM
Guha, I. N., Myers, R. P., Patel, K., & Talwalkar, J. A. (2011). Biomarkers of liver fibrosis: what lies beneath the receiver operating characteristic curve? Hepatology, 54(4), 1454–1462. https://doi.org/10.1002/hep.24515
Guha, Indra Neil, Robert P. Myers, Keyur Patel, and Jayant A. Talwalkar. “Biomarkers of liver fibrosis: what lies beneath the receiver operating characteristic curve?” Hepatology 54, no. 4 (October 2011): 1454–62. https://doi.org/10.1002/hep.24515.
Guha IN, Myers RP, Patel K, Talwalkar JA. Biomarkers of liver fibrosis: what lies beneath the receiver operating characteristic curve? Hepatology. 2011 Oct;54(4):1454–62.
Guha, Indra Neil, et al. “Biomarkers of liver fibrosis: what lies beneath the receiver operating characteristic curve?” Hepatology, vol. 54, no. 4, Oct. 2011, pp. 1454–62. Pubmed, doi:10.1002/hep.24515.
Guha IN, Myers RP, Patel K, Talwalkar JA. Biomarkers of liver fibrosis: what lies beneath the receiver operating characteristic curve? Hepatology. 2011 Oct;54(4):1454–1462.
Published In
Hepatology
DOI
EISSN
1527-3350
Publication Date
October 2011
Volume
54
Issue
4
Start / End Page
1454 / 1462
Location
United States
Related Subject Headings
- United Kingdom
- Severity of Illness Index
- ROC Curve
- Predictive Value of Tests
- Male
- Liver Cirrhosis
- Humans
- Gastroenterology & Hepatology
- Female
- Biomarkers