Antisense inhibitors, ribozymes, and siRNAs.

Journal Article (Journal Article;Review)

The current standard of care for the treatment of hepatitis C virus infection, pegylated interferon-alpha and ribavirin, is costly, associated with significant side effects, and effective in only 50% of patients. There is therefore a need for the development of novel antiviral therapies. One such approach involves the application of gene silencing technologies, including antisense oligonucleotides, ribozymes, RNA interference, and aptamers. However, despite great scientific advances over the past decade, and promising in vitro data, several significant challenges continue to limit the translation of this technology to the clinical setting. This review provides a concise update of the current literature.

Full Text

Duke Authors

Cited Authors

  • Thompson, AJV; Patel, K

Published Date

  • August 2009

Published In

Volume / Issue

  • 13 / 3

Start / End Page

  • 375 - 390

PubMed ID

  • 19628155

Electronic International Standard Serial Number (EISSN)

  • 1557-8224

Digital Object Identifier (DOI)

  • 10.1016/j.cld.2009.05.003


  • eng

Conference Location

  • United States