Role of growth factors and thrombopoietic agents in the treatment of chronic hepatitis C.

Published

Journal Article

Advanced liver disease and interferon-based treatment are both associated with varying degrees of cytopenia in patients with chronic hepatitis C. Growth factors to increase hemoglobin and neutrophils are commonly used in clinical practice, despite the absence of data to indicate benefits in terms of sustained viral response. Thrombocytopenia is observed frequently, is multi-factorial in etiology, and may result in significant limitations on interventional and therapeutic options. A small-molecule thrombopoietin mimetic, eltrombo-pag, has demonstrated a dose-response associated increase in platelet count in a phase 2 study, allowing initiation and completion of a 12-week course of peginterferon plus ribavirin in 36%, 53%, and 65% of patients receiving 30 mg, 50 mg, or 75 mg of eltrombopag daily, respectively, compared with 6% in the placebo arm. Phase 3 studies are currently evaluating whether initiating and maintaining antiviral therapy with eltrombopag will lead to an increase in sustained virologic response in chronic hepatitis C infection.

Full Text

Duke Authors

Cited Authors

  • Tillmann, HL; Patel, K; McHutchison, JG

Published Date

  • February 2009

Published In

Volume / Issue

  • 11 / 1

Start / End Page

  • 5 - 14

PubMed ID

  • 19166653

Pubmed Central ID

  • 19166653

Electronic International Standard Serial Number (EISSN)

  • 1534-312X

International Standard Serial Number (ISSN)

  • 1522-8037

Digital Object Identifier (DOI)

  • 10.1007/s11894-009-0002-x

Language

  • eng