Predictors of response to ziprasidone: results from a 6-week randomized double-blind, placebo-controlled trial for acute depressive mixed state.


Journal Article

INTRODUCTION: The present study is aimed at investigating possible predictors of response to ziprasidone in a sample of patients with mixed depressive state. METHODS: 72 patients were randomized to either ziprasidone or placebo and treated prospectively for 6 weeks. The clinical response and remission were defined with various clinical variables including Montgomery Asberg Depression Rating Scale. Further outcome measures included predictors of remission and other clinical variables over time. RESULTS: None of the variables under investigation were significantly associated with response or remission at 6 weeks (all p-values>0.003, respectively). CONCLUSIONS: Further investigations are warranted due to clear limitations, mostly small sample size and use of concomitant medications.

Full Text

Duke Authors

Cited Authors

  • Pae, C-U; Patkar, AA; Gilmer, W; Holtzman, N; Thommi, SB; Ghaemi, SN

Published Date

  • June 2012

Published In

Volume / Issue

  • 45 / 4

Start / End Page

  • 152 - 155

PubMed ID

  • 22294238

Pubmed Central ID

  • 22294238

Electronic International Standard Serial Number (EISSN)

  • 1439-0795

International Standard Serial Number (ISSN)

  • 0176-3679

Digital Object Identifier (DOI)

  • 10.1055/s-0031-1297984


  • eng