Quetiapine XR: current status for the treatment of major depressive disorder.

Journal Article (Journal Article;Review)

Quetiapine fumarate extended release (XR) has been approved for treatment of schizophrenia and bipolar disorder. Quetiapine may have antidepressant effects through effects on 5-HT(2A) receptor, 5-HT(1A) receptor, dopamine receptor, glutamate receptor and norepinephrine transporter. Recently, 7 large-scale randomized, double-blind, placebo (2-studies with active comparator)-controlled clinical trials have demonstrated that quetiapine XR has clinically meaningful efficacy as monotherapy and adjunct therapy to antidepressants for the treatment of adult patients with major depressive disorder (MDD). In such clinical trials, quetiapine XR was generally well tolerated, although weight gain and changes in metabolic parameters, consistent with the known profile of quetiapine, were observed in some patients. As of December 2009, the United States Food and Drug Administration has approved quetiapine XR for the adjunct treatment of MDD. From the data of currently available clinical trials, this review provides an overview of the data and clinical implications for quetiapine XR in the treatment of MDD to enhance clinicians understanding of the use of quetiapine XR in the treatment of MDD.

Full Text

Duke Authors

Cited Authors

  • Pae, C-U; Sohi, MS; Seo, H-J; Serretti, A; Patkar, AA; Steffens, DC; Masand, PS

Published Date

  • October 1, 2010

Published In

Volume / Issue

  • 34 / 7

Start / End Page

  • 1165 - 1173

PubMed ID

  • 20307622

Electronic International Standard Serial Number (EISSN)

  • 1878-4216

Digital Object Identifier (DOI)

  • 10.1016/j.pnpbp.2010.03.023


  • eng

Conference Location

  • England