Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders.


Journal Article

Epistasis, the interaction between genes, is a topic of current interest in molecular and quantitative genetics. We have further studied a previously investigated sample of 187 major depressive disorder (MDD) patients, 171 bipolar disorder (BD) patients, and 288 controls, and tried to analyze the interaction between a set of variations of independent genes: the trace amine receptor 6 (rs4305745, rs8192625, rs7452939, rs6903874, and rs6937506) and the heat shock protein 70 (rs562047, rs1061581, rs2227956). The multifactor dimensionality reduction (MDR) method was applied and the covariates associated with diagnosis were also controlled. A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders. The level of statistical significance (P < 0.001) and the testing balancing accuracy over 0.62 suggest a cautious optimism toward this result, although the possibility of false positivity warrants further analyses in independent samples.

Full Text

Duke Authors

Cited Authors

  • Pae, C-U; Drago, A; Forlani, M; Patkar, AA; Serretti, A

Published Date

  • March 5, 2010

Published In

Volume / Issue

  • 153B / 2

Start / End Page

  • 680 - 683

PubMed ID

  • 19582769

Pubmed Central ID

  • 19582769

Electronic International Standard Serial Number (EISSN)

  • 1552-485X

Digital Object Identifier (DOI)

  • 10.1002/ajmg.b.31009


  • eng

Conference Location

  • United States