DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients.

Published

Journal Article

Dysbindin gene (DTNBP1) has been associated with schizophrenia, but literature findings are inconsistent, and further analyses are required. This study is aimed to investigate if a set of DTNBP1 variations might influence clinic psychotic phenotype or treatment response in a sample of 240 Korean schizophrenic in-patients. Four variants have been selected (rs3213207; rs1011313; rs16876759; rs2619522) on the basis of previous findings of association with schizophrenia, bipolar disorder and antidepressant response. Single marker analysis gave marginal results. Haplotype analysis identified a significant association between A-A (rs3213207(A/G), rs1011313(A/G)) haplotype and lower PANSS total and positive scores at baseline (p=0.01; 0.02) and at discharge (p=0.008; 0.005). Covariate analysis revealed a more stable significant association between A-A haplotype and baseline scores. These results suggest a protective effect of A-A haplotype on psychotic positive symptoms at baseline.

Full Text

Duke Authors

Cited Authors

  • Pae, C-U; Drago, A; Kim, J-J; Patkar, AA; Jun, T-Y; Lee, C; Mandelli, L; De Ronchi, D; Paik, I-H; Serretti, A

Published Date

  • August 1, 2008

Published In

Volume / Issue

  • 440 / 2

Start / End Page

  • 150 - 154

PubMed ID

  • 18562100

Pubmed Central ID

  • 18562100

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/j.neulet.2008.05.069

Language

  • eng

Conference Location

  • Ireland