Effect of 5-haplotype of dysbindin gene (DTNBP1) polymorphisms for the susceptibility to bipolar I disorder.


Journal Article

We investigated a possible association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). Five SNPs within DTNBP1 (rs3213207, rs1011313, rs2005976, rs760761, and rs2619522) were genotyped for 151 patients with BID and 478 controls. We observed a significant protective association of the haplotype A-C-G-T-A (all SNPs, P = 0.00016) and particularly G-T-A (the last three SNP, P = 0.00007) within DTNBP1 variants investigated. Single marker and subgroup (e.g., psychotic features, age at onset, family history, etc.) analyses showed no significant association. Although the association was due to a small number of subjects, specific DTNBP1 haplotypes, previously associated with schizophrenia, may be also associated with BID. Adequately powered studies from different ethnicities will be necessary to confirm our findings.

Full Text

Duke Authors

Cited Authors

  • Pae, C-U; Serretti, A; Mandelli, L; Yu, H-S; Patkar, AA; Lee, C-U; Lee, S-J; Jun, T-Y; Lee, C; Paik, I-H; Kim, J-J

Published Date

  • July 5, 2007

Published In

Volume / Issue

  • 144B / 5

Start / End Page

  • 701 - 703

PubMed ID

  • 17192893

Pubmed Central ID

  • 17192893

International Standard Serial Number (ISSN)

  • 1552-4841

Digital Object Identifier (DOI)

  • 10.1002/ajmg.b.30439


  • eng

Conference Location

  • United States