No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals.

Published

Journal Article

Genetic research of cocaine abuse has been relatively limited among the African-American population. Since the serotonin transporter (5HTT) may be involved in modulating effects of cocaine, we investigated whether allelic variants of the 5HTT gene may confer susceptibility to cocaine dependence among African-American individuals. One hundred and fifty-six cocaine-dependent subjects and 82 controls were studied. Polymerase chain reaction-based genotyping of a variable-number-tandem-repeat (VNTR) marker yielded three alleles designated 12, 10 and 9. Genotype and allele frequencies were compared using chi-square analyses. We found no differences between subjects and controls with respect to genotype distribution (cocaine: 12/12 = 50%, 10/12 = 35.3%, 10/10 = 13.5%, 9/12 = 1.3%; controls: 12/12 = 42.7%, 10/12 = 39.0%, 10/10 = 17.1%, 9/12 = 1.2%). Similarly, allele frequencies of the VNTR marker did not differ between the two groups (cocaine: 12 = 68.3%, 10 = 31.1%, 9 = 0.6%; controls: 12 = 62.8%, 10 = 36.6%, 9 = 0.6%). Our findings do not seem to support a relationship between VNTR polymorphisms and cocaine dependence among African-American patients. Further studies involving larger samples are required to confirm our results.

Full Text

Duke Authors

Cited Authors

  • Patkar, AA; Berrettini, WH; Hoehe, M; Hill, KP; Gottheil, E; Thornton, CC; Weinstein, SP

Published Date

  • September 2002

Published In

Volume / Issue

  • 12 / 3

Start / End Page

  • 161 - 164

PubMed ID

  • 12218660

Pubmed Central ID

  • 12218660

International Standard Serial Number (ISSN)

  • 0955-8829

Digital Object Identifier (DOI)

  • 10.1097/00041444-200209000-00007

Language

  • eng

Conference Location

  • England