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National Lung Cancer Screening Trial American College of Radiology Imaging Network Specimen Biorepository originating from the Contemporary Screening for the Detection of Lung Cancer Trial (NLST, ACRIN 6654): design, intent, and availability of specimens for validation of lung cancer biomarkers.

Publication ,  Journal Article
Patz, EF; Caporaso, NE; Dubinett, SM; Massion, PP; Hirsch, FR; Minna, JD; Gatsonis, C; Duan, F; Adams, A; Apgar, C; Medina, RM; Aberle, DR
Published in: J Thorac Oncol
October 2010

Lung cancer continues to be a major public health problem, and more patients die from this disease than any other cancer. The vast majority of patients present with advanced stage disease when therapeutic options are limited and the overall 5 year survival rate remains approximately 15%. Screening with low dose helical computed tomography (CT)has been suggested for early detection, although the effect on mortality is currently under investigation. As part of the National Lung Cancer Screening Trial, a specimen biorepository including blood, sputum, and urine were collected serially for the primary purpose of validating early detection lung cancer biomarkers. In addition tumor samples have been obtained from patients diagnosed with lung cancer to be included in a tissue microarray. This commentary describes the rationale, composition, intent, and availability of specimen in the biorepository.

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Published In

J Thorac Oncol

DOI

EISSN

1556-1380

Publication Date

October 2010

Volume

5

Issue

10

Start / End Page

1502 / 1506

Location

United States

Related Subject Headings

  • Validation Studies as Topic
  • Research Design
  • Oncology & Carcinogenesis
  • Lung Neoplasms
  • Humans
  • Early Detection of Cancer
  • Biomarkers, Tumor
  • Biological Specimen Banks
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
 

Citation

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Patz, E. F., Caporaso, N. E., Dubinett, S. M., Massion, P. P., Hirsch, F. R., Minna, J. D., … Aberle, D. R. (2010). National Lung Cancer Screening Trial American College of Radiology Imaging Network Specimen Biorepository originating from the Contemporary Screening for the Detection of Lung Cancer Trial (NLST, ACRIN 6654): design, intent, and availability of specimens for validation of lung cancer biomarkers. J Thorac Oncol, 5(10), 1502–1506. https://doi.org/10.1097/JTO.0b013e3181f1c634
Patz, Edward F., Neil E. Caporaso, Steven M. Dubinett, Pierre P. Massion, Fred R. Hirsch, John D. Minna, Constantine Gatsonis, et al. “National Lung Cancer Screening Trial American College of Radiology Imaging Network Specimen Biorepository originating from the Contemporary Screening for the Detection of Lung Cancer Trial (NLST, ACRIN 6654): design, intent, and availability of specimens for validation of lung cancer biomarkers.J Thorac Oncol 5, no. 10 (October 2010): 1502–6. https://doi.org/10.1097/JTO.0b013e3181f1c634.
Journal cover image

Published In

J Thorac Oncol

DOI

EISSN

1556-1380

Publication Date

October 2010

Volume

5

Issue

10

Start / End Page

1502 / 1506

Location

United States

Related Subject Headings

  • Validation Studies as Topic
  • Research Design
  • Oncology & Carcinogenesis
  • Lung Neoplasms
  • Humans
  • Early Detection of Cancer
  • Biomarkers, Tumor
  • Biological Specimen Banks
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences