Sclerosing hemangioma of the lung: Case report and literature review


Journal Article (Review)

ABSTRACT: Sclerosing hemangioma of lung is an unusual neoplasm with distinctive morphological features. Although its histogenesis has been debated for decades, the current concept is that this is a tumor of cells with features most closely resembling type II pneumocytes. The tumor has 2 separate cellular components (surface cells and round cells) and 4 different growth patterns (solid, papillary, sclerotic, and hemorrhagic), which may be present in various degrees from one tumor to another. Both surface and round cells stain positive for TTF-1 and epithelial membrane antigen, whereas the surface cells stain strongly positive for cytokeratins and for surfactant proteins A and B. Round cells generally stain negative for cytokeratins and surfactant proteins. Ultrastructurally, the surface cells have features of type II pneumocytes with well-formed lamellar bodies, whereas the round cells are more primitive and contain dense core granules and microtubules. Despite the name of the tumor, vascular differentiation is not observed. Sclerosing hemangioma typically presents as a unilateral pulmonary nodule, but multiple and bilateral examples have been reported. Although this tumor typically behaves in a benign fashion with long-term survival expected after surgical resection, cases with lymph node metastases and more aggressive clinical behavior have been reported. This tumor has the potential for confusion with other more common and aggressive lung neoplasms, especially in cytological specimens. We report herein a case of sclerosing hemangioma of the lung with lymph node metastasis and review the literature on this unusual neoplasm. Copyright © 2012 by Lippincott Williams & Wilkins.

Full Text

Duke Authors

Cited Authors

  • Roggli, VL; Pavlisko, EN; Seaman, DM

Published Date

  • September 1, 2012

Published In

Volume / Issue

  • 17 / 5

Start / End Page

  • 192 - 197

Electronic International Standard Serial Number (EISSN)

  • 1533-4015

International Standard Serial Number (ISSN)

  • 1082-9784

Digital Object Identifier (DOI)

  • 10.1097/PCR.0b013e31826d88ad

Citation Source

  • Scopus