Reduction of orbital frontal cortex volume in geriatric depression.


Journal Article

BACKGROUND: Postmortem studies have documented abnormalities in the medial orbital frontal cortex in depressed patients. In this study we evaluated whether atrophy of this region can be identified in older depressed patients using magnetic resonance imaging. METHODS: Twenty elderly patients meeting DSM-IV criteria for major depression and 20 matched control subjects were studied. The orbital frontal cortex was measured in both hemispheres using magnetic resonance imaging. RESULTS: Depressive patients had reduced volume in the total orbital frontal cortex, right orbital frontal cortex, and left orbital frontal cortex. CONCLUSIONS: Our finding of a reduction in orbital frontal cortex volume in both sides of the brain suggests that this region of the brain may have a critical role in the development of depression and raises questions about the etiology of the changes.

Full Text

Duke Authors

Cited Authors

  • Lai, T; Payne, ME; Byrum, CE; Steffens, DC; Krishnan, KR

Published Date

  • November 15, 2000

Published In

Volume / Issue

  • 48 / 10

Start / End Page

  • 971 - 975

PubMed ID

  • 11082470

Pubmed Central ID

  • 11082470

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/s0006-3223(00)01042-8


  • eng

Conference Location

  • United States