Reversible spastic paraparesis induced by high-dose intravenous methadone


Journal Article

High doses of parenteral opioids can cause multifocal myoclonus and seizures. Spasticity has been reported in patients receiving intraspinal opioids. In this article, we describe a patient who developed reversible spastic paraparesis with prominent extensor spasms in the legs while receiving an infusion of intravenous methadone at 100 mg/hr. We discuss clinical presentation and possible pathophysiologic mechanisms of opioid side effects on the somatic motor system.

Full Text

Cited Authors

  • Manfredi, PL; Gonzales, GR; Payne, R

Published Date

  • January 1, 2001

Published In

Volume / Issue

  • 2 / 1

Start / End Page

  • 77 - 79

International Standard Serial Number (ISSN)

  • 1526-5900

Digital Object Identifier (DOI)

  • 10.1054/jpai.2001.9803

Citation Source

  • Scopus