Reversible spastic paraparesis induced by high-dose intravenous methadone

Published

Journal Article

High doses of parenteral opioids can cause multifocal myoclonus and seizures. Spasticity has been reported in patients receiving intraspinal opioids. In this article, we describe a patient who developed reversible spastic paraparesis with prominent extensor spasms in the legs while receiving an infusion of intravenous methadone at 100 mg/hr. We discuss clinical presentation and possible pathophysiologic mechanisms of opioid side effects on the somatic motor system.

Full Text

Cited Authors

  • Manfredi, PL; Gonzales, GR; Payne, R

Published Date

  • January 1, 2001

Published In

Volume / Issue

  • 2 / 1

Start / End Page

  • 77 - 79

International Standard Serial Number (ISSN)

  • 1526-5900

Digital Object Identifier (DOI)

  • 10.1054/jpai.2001.9803

Citation Source

  • Scopus