The opioid mechanism of interferon-alpha action.


Journal Article

Rats were trained to discriminate the opioid receptor agonist ethylketocyclazocine (EKC) (0.3 mg/kg body weight, intraperitoneally) from saline. Interferon-alpha (IFN-alpha), when substituted for EKC, elicited a dose-related increase in EKC-like responses. This generalization of EKC responses was blocked by the opioid antagonist naloxone (1 mg/kg). Potentiation of responses to a low dose (0.1 mg/kg) of EKC by IFN-alpha (1 x 10(6) U/kg or 0.22 nmol/kg) was also observed. Data thus indicate the involvement of opioid neurons on the action of IFN-alpha. d-Amphetamine (0.8 mg/kg) was shown to potentiate both EKC (0.1 mg/kg) and IFN-alpha (1 x 10(6) U/kg). The present study confirms our previously proposed opioid-mediated dopaminergic mechanism of IFN-alpha.

Full Text

Cited Authors

  • Ho, BT; Lu, JG; Huo, YY; Fan, SH; Meyers, CA; Tansey, LW; Payne, R; Levin, VA

Published Date

  • February 1994

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 90 - 94

PubMed ID

  • 8186436

Pubmed Central ID

  • 8186436

International Standard Serial Number (ISSN)

  • 0959-4973

Digital Object Identifier (DOI)

  • 10.1097/00001813-199402000-00014


  • eng

Conference Location

  • England