Transient mild hypothermia differentially alters mitotic activity in normal and post-ischemic hippocampal slices from neonatal rats

Journal Article (Journal Article)

The purpose of this study was to determine if mild hypothermia alters mitotic activity in normal and post-ischemic hippocampal slices. (1) Normothermic oxygen-glucose deprivation (OGD 60 min) increased mitotic activity in the hippocampus up to 4d post-OGD. (2) Mild hypothermia (33 °C for 24 h) initiated after OGD stress reduced mitotic activity compared to normothermic controls up to 8 d post-OGD. (3) Mild hypothermia stimulated mitotic activity in normal (no OGD stress) hippocampus up to 24 h post-hypothermia. In conclusion, mild transient hypothermia can increase or decrease mitotic activity depending upon the experimental condition of the hippocampal slices when hypothermia is induced. © 2010 Elsevier Ltd.

Full Text

Duke Authors

Cited Authors

  • Finch, AS; Moldovan, M; Frank, J; Bagnell, R; Katz, LM; Pearlstein, RD

Published Date

  • May 1, 2010

Published In

Volume / Issue

  • 35 / 4

Start / End Page

  • 189 - 196

International Standard Serial Number (ISSN)

  • 0306-4565

Digital Object Identifier (DOI)

  • 10.1016/j.jtherbio.2010.03.003

Citation Source

  • Scopus