[Extracellular Ca2+ signaling: first messenger in animals and plants].

Journal Article (Review;Journal Article;English Abstract)

It is well known that calcium acts as a vital intracellular second messenger that governs a large array of cellular processes. However, the molecular identification of a receptor for extracellular Ca2+, the extracellular calcium-sensing receptor, has opened up the possibility that Ca2+might also function as a messenger outside the cell. In animals, the Ca2+ sensor is the well-characterized extracellular-Ca2+- sensing receptor (CaR), a G- protein -coupled receptor originally isolated from the parathyroid gland. In addition, other receptors, channels and membrane proteins are all sensitive to external Ca2+ fluctuations. Recently, Han et al have cloned a receptor protein for extracellular calcium in Arabidopsis, which plays a key role in Ca2+-induced stomatal closing. Thus, the cloning of these receptors has prompted the consideration of Ca2+ also functioning as a 'first messenger' in animals and plants.

Full Text

Duke Authors

Cited Authors

  • Zhao, X; Pei, Z-M; He, Y-K

Published Date

  • March 2007

Published In

Volume / Issue

  • 29 / 3

Start / End Page

  • 269 - 275

PubMed ID

  • 17369145

International Standard Serial Number (ISSN)

  • 0253-9772

Digital Object Identifier (DOI)

  • 10.1360/yc-007-0269


  • chi