Prevention of postpartum depression: a pilot randomized clinical trial.


Journal Article

OBJECTIVE: The authors attempted to reduce the rate of postpartum depression in high-risk women and to increase the time to recurrence. METHOD: Nondepressed pregnant women with at least one past episode of postpartum major depression were recruited into a randomized clinical trial. Mothers were assigned randomly to a 17-week trial of sertraline or placebo immediately after birth and assessed for 20 sequential weeks with the Hamilton Rating Scale for Depression. RESULTS: Of 14 subjects who took sertraline, one (7%) suffered a recurrence. Of eight subjects who were assigned to placebo, four (50%) suffered recurrences. This difference was significant. The time to recurrence was significantly longer in the sertraline-treated women than in the placebo-treated women. CONCLUSIONS: Sertraline conferred preventive efficacy for postpartum-onset major depression beyond that of placebo.

Full Text

Cited Authors

  • Wisner, KL; Perel, JM; Peindl, KS; Hanusa, BH; Piontek, CM; Findling, RL

Published Date

  • July 1, 2004

Published In

Volume / Issue

  • 161 / 7

Start / End Page

  • 1290 - 1292

PubMed ID

  • 15229064

Pubmed Central ID

  • 15229064

Electronic International Standard Serial Number (EISSN)

  • 1535-7228

International Standard Serial Number (ISSN)

  • 0002-953X

Digital Object Identifier (DOI)

  • 10.1176/appi.ajp.161.7.1290


  • eng