Antigens and surface components associated with virulence of Actinomyces viscosus.


Journal Article

We have isolated a specific cell wall antigen of high molecular weight which appears to be unique to virulent strains of A viscosus and A naeslundii. The antigen is composed of two parts: a polysaccharide moiety containing 6-DOT as the major sugar and determinant of serologic specificity, and a small peptide bearing some resemblance to the peptidoglycan. Other data indicate a positive correlation between the presence of this antigen and an extrachromosomal piece of DNA having most of the properties of a bacterial plasmid. The specific function of the 6-DOT antigen in disease production is not known, but its clear association with virulent strains suggests the possibility of monitoring specific populations of oral actinomycetes.

Full Text

Cited Authors

  • Hammond, BF; Steel, CF; Peindl, KS

Published Date

  • January 1, 1976

Published In

Volume / Issue

  • 55 /

Start / End Page

  • A19 - A25

PubMed ID

  • 1060640

Pubmed Central ID

  • 1060640

Electronic International Standard Serial Number (EISSN)

  • 1544-0591

International Standard Serial Number (ISSN)

  • 0022-0345

Digital Object Identifier (DOI)

  • 10.1177/002203457605500111011


  • eng