Right ventricular sensitivity to metabolic injury during cardiopulmonary bypass.

Published

Journal Article

To determine intrinsic right ventricular susceptibility to metabolic injury, we examined the effect of ischemia and reperfusion during cardiopulmonary bypass on right and left ventricular myocardial adenine nucleotide metabolism in the absence of ventricular work load as a determinant of energy production and utilization. Dogs were subjected either to 30 minutes of normothermic or hypothermic myocardial ischemia and reperfusion or to 60 minutes of potassium-arrested normothermic ischemia; serial ventricular biopsy specimens were assayed for adenosine triphosphate, adenosine diphosphate, adenosine monophosphate, nucleoside, and base content. In each group the depletion rates of right and left ventricular nucleotides with ischemia did not differ. Mitochondrial ability to rephosphorylate the nucleotide pool during and after ischemia also did not differ in the two ventricles, and there were no detectable differences in the catabolism of nucleotide precursors and loss of total purine content with reperfusion. These observations indicate that right ventricular myocardium is as equally sensitive to ischemic and reperfusion injury as left ventricular myocardium, and metabolic recovery from injury is equally prolonged.

Full Text

Duke Authors

Cited Authors

  • Morris, JJ; Hamm, DP; Pellom, GL; Abd-Elfattah, A; Wechsler, AS

Published Date

  • March 1, 1986

Published In

Volume / Issue

  • 121 / 3

Start / End Page

  • 338 - 344

PubMed ID

  • 3947231

Pubmed Central ID

  • 3947231

International Standard Serial Number (ISSN)

  • 0004-0010

Digital Object Identifier (DOI)

  • 10.1001/archsurg.1986.01400030092016

Language

  • eng

Conference Location

  • United States