Correlation of mitochondrial function and ischemic contracture.

Published

Journal Article

Structural and functional changes in the mitochondrium have been described following timed cardiac ischemia. However, mitochondrial abnormalities associated with acute muscular dysfunction have not been well defined. In the present investigation, the isolated rat heart subjected to global ischemia was used to determine the relationship between the biochemical parameters of high-energy phosphate content and mitochondrial function and the physiological event of ischemic contracture. High-energy phosphate content and mitochondrial structure and function were determined under control conditions, at the initiation of ischemic contracture, at the completion of ischemic contracture, and 20 minutes after completion of contracture. Contracture initiation and completion were associated with the anticipated depletion of high-energy phosphate content. Also demonstrated were specific degrees of structural and functional deterioration of the mitochondria associated with specific degrees of contracture. In addition to its prior applications, this model seems well suited for investigation of the interdependence of high-energy phosphate levels, ischemic contracture, and mitochondrial function as affected by specific protective interventions designed to limit ischemic injury.

Full Text

Duke Authors

Cited Authors

  • Sink, JD; Currie, WD; Pellom, GL; Hill, RC; Chitwood, WR; Wechsler, AS

Published Date

  • April 1980

Published In

Volume / Issue

  • 79 / 4

Start / End Page

  • 570 - 578

PubMed ID

  • 7359935

Pubmed Central ID

  • 7359935

International Standard Serial Number (ISSN)

  • 0022-5223

Language

  • eng

Conference Location

  • United States