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Abl tyrosine kinases in T-cell signaling.

Publication ,  Journal Article
Gu, JJ; Ryu, JR; Pendergast, AM
Published in: Immunol Rev
March 2009

Stimulation of the T-cell antigen receptor (TCR) leads to the activation of signaling pathways that are essential for T-cell development and the response of mature T cells to antigens. The TCR has no intrinsic catalytic activity, but TCR engagement results in tyrosine phosphorylation of downstream targets by non-receptor tyrosine kinases. Three families of tyrosine kinases have long been recognized to play critical roles in TCR-dependent signaling. They are the Src, zeta-associated protein of 70 kDa, and Tec families of kinases. More recently, the Abelson (Abl) tyrosine kinases have been shown to be activated by TCR engagement and to be required for maximal TCR signaling. Using T-cell conditional knockout mice deficient for Abl family kinases, Abl (Abl1) and Abl-related gene (Arg) (Abl2), it was recently shown that loss of Abl kinases results in defective T-cell development and a partial block in the transition to the CD4(+)CD8(+) stage. Abl/Arg double null T cells exhibit impaired TCR-induced signaling, proliferation, and cytokine production. Moreover, conditional knockout mice lacking Abl and Arg in T cells exhibit impaired CD8(+) T-cell expansion in vivo upon Listeria monocytogenes infection. Thus, Abl kinase signaling is required for both T-cell development and mature T-cell function.

Duke Scholars

Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

March 2009

Volume

228

Issue

1

Start / End Page

170 / 183

Location

England

Related Subject Headings

  • T-Lymphocytes
  • Signal Transduction
  • Proto-Oncogene Proteins c-abl
  • Immunology
  • Humans
  • Animals
  • 3204 Immunology
  • 1107 Immunology
 

Citation

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Gu, J. J., Ryu, J. R., & Pendergast, A. M. (2009). Abl tyrosine kinases in T-cell signaling. Immunol Rev, 228(1), 170–183. https://doi.org/10.1111/j.1600-065X.2008.00751.x
Gu, Jing Jin, Jae Ryun Ryu, and Ann Marie Pendergast. “Abl tyrosine kinases in T-cell signaling.Immunol Rev 228, no. 1 (March 2009): 170–83. https://doi.org/10.1111/j.1600-065X.2008.00751.x.
Gu JJ, Ryu JR, Pendergast AM. Abl tyrosine kinases in T-cell signaling. Immunol Rev. 2009 Mar;228(1):170–83.
Gu, Jing Jin, et al. “Abl tyrosine kinases in T-cell signaling.Immunol Rev, vol. 228, no. 1, Mar. 2009, pp. 170–83. Pubmed, doi:10.1111/j.1600-065X.2008.00751.x.
Gu JJ, Ryu JR, Pendergast AM. Abl tyrosine kinases in T-cell signaling. Immunol Rev. 2009 Mar;228(1):170–183.
Journal cover image

Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

March 2009

Volume

228

Issue

1

Start / End Page

170 / 183

Location

England

Related Subject Headings

  • T-Lymphocytes
  • Signal Transduction
  • Proto-Oncogene Proteins c-abl
  • Immunology
  • Humans
  • Animals
  • 3204 Immunology
  • 1107 Immunology