Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria.

Journal Article (Journal Article;Review)

Invasive fungal diseases (IFDs) have become major causes of morbidity and mortality among highly immunocompromised patients. Authoritative consensus criteria to diagnose IFD have been useful in establishing eligibility criteria for antifungal trials. There is an important need for generation of consensus definitions of outcomes of IFD that will form a standard for evaluating treatment success and failure in clinical trials. Therefore, an expert international panel consisting of the Mycoses Study Group and the European Organization for Research and Treatment of Cancer was convened to propose guidelines for assessing treatment responses in clinical trials of IFDs and for defining study outcomes. Major fungal diseases that are discussed include invasive disease due to Candida species, Aspergillus species and other molds, Cryptococcus neoformans, Histoplasma capsulatum, and Coccidioides immitis. We also discuss potential pitfalls in assessing outcome, such as conflicting clinical, radiological, and/or mycological data and gaps in knowledge.

Full Text

Duke Authors

Cited Authors

  • Segal, BH; Herbrecht, R; Stevens, DA; Ostrosky-Zeichner, L; Sobel, J; Viscoli, C; Walsh, TJ; Maertens, J; Patterson, TF; Perfect, JR; Dupont, B; Wingard, JR; Calandra, T; Kauffman, CA; Graybill, JR; Baden, LR; Pappas, PG; Bennett, JE; Kontoyiannis, DP; Cordonnier, C; Viviani, MA; Bille, J; Almyroudis, NG; Wheat, LJ; Graninger, W; Bow, EJ; Holland, SM; Kullberg, B-J; Dismukes, WE; De Pauw, BE

Published Date

  • September 1, 2008

Published In

Volume / Issue

  • 47 / 5

Start / End Page

  • 674 - 683

PubMed ID

  • 18637757

Pubmed Central ID

  • PMC2671230

Electronic International Standard Serial Number (EISSN)

  • 1537-6591

Digital Object Identifier (DOI)

  • 10.1086/590566


  • eng

Conference Location

  • United States