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Management of invasive mycoses in hematology patients: current approaches.

Publication ,  Journal Article
Perfect, JR
Published in: Oncology (Williston Park)
November 2004

Candidiasis and aspergillosis are the most common fungal infections in hematopoietic stem cell transplant recipients and other hematology/oncology patients. Strategies for reducing the morbidity and mortality associated with these infections include antifungal prophylaxis, empiric therapy in patients with persistent fever and neutropenia, and preemptive therapy. Antifungal therapies include amphotericin B deoxycholate, lipid formulations of amphotericin B, the triazoles (fluconazole, itraconazole, and voriconazole), and the echinocandins (caspofungin and the investigational agents micafungin and anidulafungin). Fluconazole is a reasonable choice for the treatment of invasive candidiasis if the patient has not previously received a triazole and the institution has a low incidence of triazole resistance. If resistance is a concern, an echinocandin, such as caspofungin, is an appropriate option. Voriconazole may be the initial choice in most patients with invasive aspergillosis. If patients are intolerant of or refractory to conventional therapy, effective alternatives include a lipid formulation of amphotericin B or an echinocandin.

Duke Scholars

Published In

Oncology (Williston Park)

ISSN

0890-9091

Publication Date

November 2004

Volume

18

Issue

13 Suppl 7

Start / End Page

5 / 14

Location

United States

Related Subject Headings

  • Triazoles
  • Survival Analysis
  • Randomized Controlled Trials as Topic
  • Peptides, Cyclic
  • Neutropenia
  • Neoplasms
  • Mycoses
  • Liposomes
  • Humans
  • Hematopoietic Stem Cell Transplantation
 

Citation

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Perfect, J. R. (2004). Management of invasive mycoses in hematology patients: current approaches. Oncology (Williston Park), 18(13 Suppl 7), 5–14.
Perfect, John R. “Management of invasive mycoses in hematology patients: current approaches.Oncology (Williston Park) 18, no. 13 Suppl 7 (November 2004): 5–14.
Perfect JR. Management of invasive mycoses in hematology patients: current approaches. Oncology (Williston Park). 2004 Nov;18(13 Suppl 7):5–14.
Perfect, John R. “Management of invasive mycoses in hematology patients: current approaches.Oncology (Williston Park), vol. 18, no. 13 Suppl 7, Nov. 2004, pp. 5–14.
Perfect JR. Management of invasive mycoses in hematology patients: current approaches. Oncology (Williston Park). 2004 Nov;18(13 Suppl 7):5–14.

Published In

Oncology (Williston Park)

ISSN

0890-9091

Publication Date

November 2004

Volume

18

Issue

13 Suppl 7

Start / End Page

5 / 14

Location

United States

Related Subject Headings

  • Triazoles
  • Survival Analysis
  • Randomized Controlled Trials as Topic
  • Peptides, Cyclic
  • Neutropenia
  • Neoplasms
  • Mycoses
  • Liposomes
  • Humans
  • Hematopoietic Stem Cell Transplantation