Skip to main content

Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide.

Publication ,  Journal Article
Steinbach, WJ; Schell, WA; Miller, JL; Perfect, JR
Published in: J Clin Microbiol
August 2003

Scedosporium species are increasingly isolated from immunocompromised and immunocompetent patients. Unfortunately, Scedosporium infections are generally resistant to amphotericin B, and Scedosporium prolificans strains are particularly resistant to the antifungal agents now in use. We report here on an immunocompetent child with S. prolificans-associated osteomyelitis successfully treated with debridement, local irrigation with polyhexamethylene biguanide, and the systemic administration of voriconazole and caspofungin despite poor in vitro activity of voriconazole alone against the isolate. We also review the treatments and outcomes of 28 reported cases of osteomyelitis or septic arthritis caused by Scedosporium species in immunocompetent patients.

Duke Scholars

Published In

J Clin Microbiol

DOI

ISSN

0095-1137

Publication Date

August 2003

Volume

41

Issue

8

Start / End Page

3981 / 3985

Location

United States

Related Subject Headings

  • Voriconazole
  • Triazoles
  • Scedosporium
  • Pyrimidines
  • Peptides, Cyclic
  • Peptides
  • Osteomyelitis
  • Mucormycosis
  • Microbiology
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Steinbach, W. J., Schell, W. A., Miller, J. L., & Perfect, J. R. (2003). Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide. J Clin Microbiol, 41(8), 3981–3985. https://doi.org/10.1128/JCM.41.8.3981-3985.2003
Steinbach, William J., Wiley A. Schell, Jackie L. Miller, and John R. Perfect. “Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide.J Clin Microbiol 41, no. 8 (August 2003): 3981–85. https://doi.org/10.1128/JCM.41.8.3981-3985.2003.
Steinbach, William J., et al. “Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide.J Clin Microbiol, vol. 41, no. 8, Aug. 2003, pp. 3981–85. Pubmed, doi:10.1128/JCM.41.8.3981-3985.2003.

Published In

J Clin Microbiol

DOI

ISSN

0095-1137

Publication Date

August 2003

Volume

41

Issue

8

Start / End Page

3981 / 3985

Location

United States

Related Subject Headings

  • Voriconazole
  • Triazoles
  • Scedosporium
  • Pyrimidines
  • Peptides, Cyclic
  • Peptides
  • Osteomyelitis
  • Mucormycosis
  • Microbiology
  • Male