Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide.

Journal Article (Journal Article;Review)

Scedosporium species are increasingly isolated from immunocompromised and immunocompetent patients. Unfortunately, Scedosporium infections are generally resistant to amphotericin B, and Scedosporium prolificans strains are particularly resistant to the antifungal agents now in use. We report here on an immunocompetent child with S. prolificans-associated osteomyelitis successfully treated with debridement, local irrigation with polyhexamethylene biguanide, and the systemic administration of voriconazole and caspofungin despite poor in vitro activity of voriconazole alone against the isolate. We also review the treatments and outcomes of 28 reported cases of osteomyelitis or septic arthritis caused by Scedosporium species in immunocompetent patients.

Full Text

Duke Authors

Cited Authors

  • Steinbach, WJ; Schell, WA; Miller, JL; Perfect, JR

Published Date

  • August 2003

Published In

Volume / Issue

  • 41 / 8

Start / End Page

  • 3981 - 3985

PubMed ID

  • 12904435

Pubmed Central ID

  • PMC179776

International Standard Serial Number (ISSN)

  • 0095-1137

Digital Object Identifier (DOI)

  • 10.1128/JCM.41.8.3981-3985.2003


  • eng

Conference Location

  • United States