Knockout mice as experimental models of virulence.


Journal Article (Review)

Infection models with animals whose immune systems have been selectively altered by neutralization of endogenous cytokines or by deletion of a gene have provided a valuable means to study the function of cells or cytokines in the context of complex multidimensional interactions. In particular, knockout mice have allowed a deeper insight into the in vivo performance of antifungal innate and acquired immunity, whose interplay is considered fundamental in the general defense against infections. It is conceivable that such an integrated view of effector and regulatory immune mechanisms operating in opportunistic fungal infections would facilitate the search for cells, cytokines and molecular pathways that are essential to control fungal infectivity or oppose fungus-associated immunopathology.

Full Text

Duke Authors

Cited Authors

  • Deepe, GS; Romani, L; Calich, VL; Huffnagle, G; Arruda, C; Molinari-Madlum, EE; Perfect, JR

Published Date

  • 2000

Published In

Volume / Issue

  • 38 Suppl 1 /

Start / End Page

  • 87 - 98

PubMed ID

  • 11204168

Pubmed Central ID

  • 11204168

International Standard Serial Number (ISSN)

  • 1369-3786


  • eng

Conference Location

  • England