In vitro and in vivo efficacy of the triazole TAK-187 against Cryptococcus neoformans.

Journal Article

Multiple isolates of Cryptococcus neoformans, including those with fluconazole resistance, were tested to assess the in vitro activity of the new triazole TAK-187. MICs of TAK-187 were at least eightfold lower than those of fluconazole, and fungicidal concentrations for most isolates were 4 microg/ml or less. TAK-187 also was evaluated as intermittent therapy using two dosages in a rabbit model of experimental cryptococcal meningitis. Compared to daily treatment with fluconazole, as little as two doses of TAK-187 given 7 days apart were found to be effective. Plasma and cerebrospinal fluid TAK-187 concentrations were many times higher than MICs and fungicidal concentrations. Based upon its therapeutic efficacy and long half-life in the rabbit model, TAK-187 should be investigated for intermittent dosing in treatment or suppression of cryptococcal infections in humans.

Full Text

Duke Authors

Cited Authors

  • Schell, WA; De Almeida, GM; Dodge, RK; Okonogi, K; Perfect, JR

Published Date

  • October 1998

Published In

Volume / Issue

  • 42 / 10

Start / End Page

  • 2630 - 2632

PubMed ID

  • 9756767

International Standard Serial Number (ISSN)

  • 0066-4804

Language

  • eng

Conference Location

  • United States