Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.


Journal Article

Twenty analogues of pentamidine, 7 primary metabolites of pentamidine, and 30 dicationic substituted bis-benzimidazoles were screened for their inhibitory and fungicidal activities against Candida albicans and Cryptococcus neoformans. A majority of the compounds had MICs at which 80% of the strains were inhibited (MIC80s) comparable to those of amphotericin B and fluconazole. Unlike fluconazole, many of these compounds were found to have potent fungicidal activity. The most potent compound against C. albicans had an MIC80 of

Full Text

Duke Authors

Cited Authors

  • Del Poeta, M; Schell, WA; Dykstra, CC; Jones, S; Tidwell, RR; Czarny, A; Bajic, M; Kumar, A; Boykin, D; Perfect, JR

Published Date

  • October 1998

Published In

Volume / Issue

  • 42 / 10

Start / End Page

  • 2495 - 2502

PubMed ID

  • 9756747

Pubmed Central ID

  • 9756747

International Standard Serial Number (ISSN)

  • 0066-4804


  • eng

Conference Location

  • United States