Uptake of itraconazole by alveolar macrophages.

Journal Article (Journal Article)

Itraconazole is a broad-spectrum potent triazole antifungal agent. Its efficacy in treatment cannot always be explained by body fluid drug levels. In this study, itraconazole was shown to accumulate into host cells. Its intracellular accumulation in cells is greater than that of the antibacterial agent clindamycin, which is known for intracellular localization, and the uptake process does not appear to be active. This ability to reach high concentrations intracellularly may be an important property for the in vivo efficacy of itraconazole.

Full Text

Duke Authors

Cited Authors

  • Perfect, JR; Savani, DV; Durack, DT

Published Date

  • April 1993

Published In

Volume / Issue

  • 37 / 4

Start / End Page

  • 903 - 904

PubMed ID

  • 8388205

Pubmed Central ID

  • PMC187808

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/AAC.37.4.903

Language

  • eng

Conference Location

  • United States