Uptake of itraconazole by alveolar macrophages.
Publication
, Journal Article
Perfect, JR; Savani, DV; Durack, DT
Published in: Antimicrob Agents Chemother
April 1993
Itraconazole is a broad-spectrum potent triazole antifungal agent. Its efficacy in treatment cannot always be explained by body fluid drug levels. In this study, itraconazole was shown to accumulate into host cells. Its intracellular accumulation in cells is greater than that of the antibacterial agent clindamycin, which is known for intracellular localization, and the uptake process does not appear to be active. This ability to reach high concentrations intracellularly may be an important property for the in vivo efficacy of itraconazole.
Duke Scholars
Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
April 1993
Volume
37
Issue
4
Start / End Page
903 / 904
Location
United States
Related Subject Headings
- Rabbits
- Mycobacterium bovis
- Microbiology
- Macrophages, Alveolar
- Ketoconazole
- Itraconazole
- In Vitro Techniques
- Erythrocytes
- Colony Count, Microbial
- Clindamycin
Citation
APA
Chicago
ICMJE
MLA
NLM
Perfect, J. R., Savani, D. V., & Durack, D. T. (1993). Uptake of itraconazole by alveolar macrophages. Antimicrob Agents Chemother, 37(4), 903–904. https://doi.org/10.1128/AAC.37.4.903
Perfect, J. R., D. V. Savani, and D. T. Durack. “Uptake of itraconazole by alveolar macrophages.” Antimicrob Agents Chemother 37, no. 4 (April 1993): 903–4. https://doi.org/10.1128/AAC.37.4.903.
Perfect JR, Savani DV, Durack DT. Uptake of itraconazole by alveolar macrophages. Antimicrob Agents Chemother. 1993 Apr;37(4):903–4.
Perfect, J. R., et al. “Uptake of itraconazole by alveolar macrophages.” Antimicrob Agents Chemother, vol. 37, no. 4, Apr. 1993, pp. 903–04. Pubmed, doi:10.1128/AAC.37.4.903.
Perfect JR, Savani DV, Durack DT. Uptake of itraconazole by alveolar macrophages. Antimicrob Agents Chemother. 1993 Apr;37(4):903–904.
Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
April 1993
Volume
37
Issue
4
Start / End Page
903 / 904
Location
United States
Related Subject Headings
- Rabbits
- Mycobacterium bovis
- Microbiology
- Macrophages, Alveolar
- Ketoconazole
- Itraconazole
- In Vitro Techniques
- Erythrocytes
- Colony Count, Microbial
- Clindamycin