Uptake of itraconazole by alveolar macrophages.
Published
Journal Article
Itraconazole is a broad-spectrum potent triazole antifungal agent. Its efficacy in treatment cannot always be explained by body fluid drug levels. In this study, itraconazole was shown to accumulate into host cells. Its intracellular accumulation in cells is greater than that of the antibacterial agent clindamycin, which is known for intracellular localization, and the uptake process does not appear to be active. This ability to reach high concentrations intracellularly may be an important property for the in vivo efficacy of itraconazole.
Full Text
Duke Authors
Cited Authors
- Perfect, JR; Savani, DV; Durack, DT
Published Date
- April 1993
Published In
Volume / Issue
- 37 / 4
Start / End Page
- 903 - 904
PubMed ID
- 8388205
Pubmed Central ID
- 8388205
International Standard Serial Number (ISSN)
- 0066-4804
Digital Object Identifier (DOI)
- 10.1128/aac.37.4.903
Language
- eng
Conference Location
- United States