Fluconazole therapy for experimental cryptococcosis and candidiasis in the rabbit.

Journal Article (Journal Article;Review)

Fluconazole is a second-generation azole compound with broad-spectrum antifungal activity. It has been examined in several animal models emphasizing important clinical sites of infection with common yeast pathogens. The drug has an excellent pharmacokinetic profile for central nervous system, renal, and ocular infections; at these sites fluconazole has been successful in the treatment of infections with Cryptococcus neoformans or Candida albicans. On the basis of the experience in animals, fluconazole should be critically evaluated in the treatment of human mycoses such as cryptococcosis of the central nervous system and renal/ocular candidiasis. This agent represents the new wave of interest in the increasingly troublesome problem of deep-seated fungal infections.

Full Text

Duke Authors

Cited Authors

  • Perfect, JR

Published Date

  • March 1990

Published In

Volume / Issue

  • 12 Suppl 3 /

Start / End Page

  • S299 - S302

PubMed ID

  • 2184508

International Standard Serial Number (ISSN)

  • 0162-0886

Digital Object Identifier (DOI)

  • 10.1093/clinids/12.supplement_3.s299


  • eng

Conference Location

  • United States