Disseminated zygomycosis: report of four cases and review.

Journal Article (Journal Article;Review)

We present four cases of disseminated zygomycosis that illustrate the characteristic clinical syndromes and natural history of this infection. The zygomycetes affect individuals immunosuppressed by age, drug therapy, or underlying disease. A previous splenectomy or deferoxamine therapy may be an additional factor in the development of disseminated zygomycosis. Clinical syndromes reflect vascular invasion and organ infarction. Diagnosis requires consideration of risk factors followed by biopsy of the affected organ for culture and for demonstration of broad nonseptate hyphae in tissue sections. Despite advances in the management of many bacterial and fungal infections in the immunosuppressed host, the results of therapy for disseminated zygomycosis remain dismal.

Full Text

Duke Authors

Cited Authors

  • Ingram, CW; Sennesh, J; Cooper, JN; Perfect, JR

Published Date

  • 1989

Published In

Volume / Issue

  • 11 / 5

Start / End Page

  • 741 - 754

PubMed ID

  • 2682947

International Standard Serial Number (ISSN)

  • 0162-0886

Digital Object Identifier (DOI)

  • 10.1093/clinids/11.5.741


  • eng

Conference Location

  • United States