A meta-analysis of zinc salts lozenges and the common cold.

Journal Article (Journal Article)

BACKGROUND: In the United States, the common cold has been estimated to cost more than $3.5 billion a year. Despite several randomized clinical trials, the effect of treating colds with zinc salts lozenges remains uncertain because of conflicting results. OBJECTIVE: To conduct a meta-analysis of published randomized clinical trials on the use of zinc salts lozenges in colds using a random effects model. RESULTS: Eight clinical trials of treating adults with zinc salts lozenges were identified. After excluding 2 studies that used nasal inoculation of rhinovirus, 6 trials were combined and analyzed. The summary odds ratio for the presence of any cold symptoms at 7 days was 0.50 (95% confidence interval, 0.19-1.29). CONCLUSION: Despite numerous randomized trials, the evidence for effectiveness of zinc salts lozenges in reducing the duration of common colds is still lacking.

Full Text

Duke Authors

Cited Authors

  • Jackson, JL; Peterson, C; Lesho, E

Published Date

  • November 10, 1997

Published In

Volume / Issue

  • 157 / 20

Start / End Page

  • 2373 - 2376

PubMed ID

  • 9361579

International Standard Serial Number (ISSN)

  • 0003-9926


  • eng

Conference Location

  • United States