Haploidization in Saccharomyces cerevisiae induced by a deficiency in homologous recombination.

Journal Article (Journal Article)

Diploid Saccharomyes cerevisae strains lacking the RAD52 gene required for homologous recombination have a very high rate of chromosome loss. Two of four isolates subcultured ∼20 times (∼500 cell divisions) became haploid. These strains were capable of mating with wild-type haploids to produce diploid progeny capable of undergoing meiosis to produce four viable spores.

Full Text

Duke Authors

Cited Authors

  • Song, W; Petes, TD

Published Date

  • May 2012

Published In

Volume / Issue

  • 191 / 1

Start / End Page

  • 279 - 284

PubMed ID

  • 22367034

Pubmed Central ID

  • PMC3338266

Electronic International Standard Serial Number (EISSN)

  • 1943-2631

Digital Object Identifier (DOI)

  • 10.1534/genetics.111.138180


  • eng

Conference Location

  • United States