Reciprocal uniparental disomy in yeast.

Journal Article (Journal Article)

In the diploid cells of most organisms, including humans, each chromosome is usually distinguishable from its partner homolog by multiple single-nucleotide polymorphisms. One common type of genetic alteration observed in tumor cells is uniparental disomy (UPD), in which a pair of homologous chromosomes are derived from a single parent, resulting in loss of heterozygosity for all single-nucleotide polymorphisms while maintaining diploidy. Somatic UPD events are usually explained as reflecting two consecutive nondisjunction events. Here we report a previously undescribed mode of chromosome segregation in Saccharomyces cerevisiae in which one cell division produces daughter cells with reciprocal UPD for the same pair of chromosomes without an aneuploid intermediate. One pair of sister chromatids is segregated into one daughter cell and the other pair is segregated into the other daughter cell, mimicking a meiotic chromosome segregation pattern. We term this process "reciprocal uniparental disomy."

Full Text

Duke Authors

Cited Authors

  • Andersen, SL; Petes, TD

Published Date

  • June 19, 2012

Published In

Volume / Issue

  • 109 / 25

Start / End Page

  • 9947 - 9952

PubMed ID

  • 22665764

Pubmed Central ID

  • PMC3382553

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

Digital Object Identifier (DOI)

  • 10.1073/pnas.1207736109


  • eng

Conference Location

  • United States