The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast.


Journal Article

The Mre11p/Rad50p/Xrs2p complex is involved in the repair of double-strand DNA breaks, nonhomologous end joining, and telomere length regulation. TEL1 is primarily involved in telomere length regulation. By an epistasis analysis, we conclude that Tel1p and the Mre11p/Rad50p/Xrs2p complex function in a single pathway of telomere length regulation.

Full Text

Duke Authors

Cited Authors

  • Ritchie, KB; Petes, TD

Published Date

  • May 2000

Published In

Volume / Issue

  • 155 / 1

Start / End Page

  • 475 - 479

PubMed ID

  • 10790418

Pubmed Central ID

  • 10790418

International Standard Serial Number (ISSN)

  • 0016-6731


  • eng

Conference Location

  • United States