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Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae.

Publication ,  Journal Article
Gerton, JL; DeRisi, J; Shroff, R; Lichten, M; Brown, PO; Petes, TD
Published in: Proc Natl Acad Sci U S A
October 10, 2000

In the yeast Saccharomyces cerevisiae, meiotic recombination is initiated by double-strand DNA breaks (DSBs). Meiotic DSBs occur at relatively high frequencies in some genomic regions (hotspots) and relatively low frequencies in others (coldspots). We used DNA microarrays to estimate variation in the level of nearby meiotic DSBs for all 6,200 yeast genes. Hotspots were nonrandomly associated with regions of high G + C base composition and certain transcriptional profiles. Coldspots were nonrandomly associated with the centromeres and telomeres.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

October 10, 2000

Volume

97

Issue

21

Start / End Page

11383 / 11390

Location

United States

Related Subject Headings

  • Saccharomyces cerevisiae
  • Recombination, Genetic
  • Nucleic Acid Hybridization
  • Meiosis
  • DNA Primers
  • DNA Damage
  • Chromosome Mapping
  • Base Sequence
 

Citation

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ICMJE
MLA
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Gerton, J. L., DeRisi, J., Shroff, R., Lichten, M., Brown, P. O., & Petes, T. D. (2000). Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A, 97(21), 11383–11390. https://doi.org/10.1073/pnas.97.21.11383
Gerton, J. L., J. DeRisi, R. Shroff, M. Lichten, P. O. Brown, and T. D. Petes. “Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae.Proc Natl Acad Sci U S A 97, no. 21 (October 10, 2000): 11383–90. https://doi.org/10.1073/pnas.97.21.11383.
Gerton JL, DeRisi J, Shroff R, Lichten M, Brown PO, Petes TD. Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11383–90.
Gerton, J. L., et al. “Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae.Proc Natl Acad Sci U S A, vol. 97, no. 21, Oct. 2000, pp. 11383–90. Pubmed, doi:10.1073/pnas.97.21.11383.
Gerton JL, DeRisi J, Shroff R, Lichten M, Brown PO, Petes TD. Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11383–11390.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

October 10, 2000

Volume

97

Issue

21

Start / End Page

11383 / 11390

Location

United States

Related Subject Headings

  • Saccharomyces cerevisiae
  • Recombination, Genetic
  • Nucleic Acid Hybridization
  • Meiosis
  • DNA Primers
  • DNA Damage
  • Chromosome Mapping
  • Base Sequence