Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae.
Publication
, Journal Article
Gerton, JL; DeRisi, J; Shroff, R; Lichten, M; Brown, PO; Petes, TD
Published in: Proc Natl Acad Sci U S A
October 10, 2000
In the yeast Saccharomyces cerevisiae, meiotic recombination is initiated by double-strand DNA breaks (DSBs). Meiotic DSBs occur at relatively high frequencies in some genomic regions (hotspots) and relatively low frequencies in others (coldspots). We used DNA microarrays to estimate variation in the level of nearby meiotic DSBs for all 6,200 yeast genes. Hotspots were nonrandomly associated with regions of high G + C base composition and certain transcriptional profiles. Coldspots were nonrandomly associated with the centromeres and telomeres.
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Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
October 10, 2000
Volume
97
Issue
21
Start / End Page
11383 / 11390
Location
United States
Related Subject Headings
- Saccharomyces cerevisiae
- Recombination, Genetic
- Nucleic Acid Hybridization
- Meiosis
- DNA Primers
- DNA Damage
- Chromosome Mapping
- Base Sequence
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APA
Chicago
ICMJE
MLA
NLM
Gerton, J. L., DeRisi, J., Shroff, R., Lichten, M., Brown, P. O., & Petes, T. D. (2000). Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A, 97(21), 11383–11390. https://doi.org/10.1073/pnas.97.21.11383
Gerton, J. L., J. DeRisi, R. Shroff, M. Lichten, P. O. Brown, and T. D. Petes. “Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae.” Proc Natl Acad Sci U S A 97, no. 21 (October 10, 2000): 11383–90. https://doi.org/10.1073/pnas.97.21.11383.
Gerton JL, DeRisi J, Shroff R, Lichten M, Brown PO, Petes TD. Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11383–90.
Gerton, J. L., et al. “Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae.” Proc Natl Acad Sci U S A, vol. 97, no. 21, Oct. 2000, pp. 11383–90. Pubmed, doi:10.1073/pnas.97.21.11383.
Gerton JL, DeRisi J, Shroff R, Lichten M, Brown PO, Petes TD. Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11383–11390.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
October 10, 2000
Volume
97
Issue
21
Start / End Page
11383 / 11390
Location
United States
Related Subject Headings
- Saccharomyces cerevisiae
- Recombination, Genetic
- Nucleic Acid Hybridization
- Meiosis
- DNA Primers
- DNA Damage
- Chromosome Mapping
- Base Sequence